Buszko Katarzyna, Kujawski Sławomir, Newton Julia L, Zalewski Paweł
Department of Theoretical Foundations of Bio-Medical Science and Medical Informatics, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Division of Ergonomics and Exercise Physiology, Department of Hygiene, Epidemiology and Ergonomics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Front Physiol. 2019 Mar 7;10:184. doi: 10.3389/fphys.2019.00184. eCollection 2019.
The paper presents a meta-analysis of studies comparing hemodynamic parameters: heart rate (HR), systolic blood pressure (sBP), diastolic blood pressure (dBP), and stroke volume (SV) measured during head-up tilt table test (HUTT) in patients with positive and negative HUT test outcome. Pubmed and Clinical Key databases were searched for English-only articles presenting results of biosignals measurements during tilt test in patients suffering from syncope. From 3,289 articles 13 articles published between 1997 and 2015 investigating 892 patients (467 with positive HUTT outcome and 401 with negative one) were selected. There were not statistically significant differences observed between the parameters measured in supine position in patients with positive and negative test outcome [HR ( = 0.86), sBP ( = 0.32), dBP ( = 0.21), SV ( = 0.71)]. In tilt position the parameters HR and SV were significantly different when compared between the two groups of patients [HR ( = 0.02), sBP ( = 0.10), dBP ( = 0.59), SV ( = 0.0004)]. Changes in HR and SV parameters in response to tilt test turned out to be statistically significant. In supine position the differences between patients with positive and negative test outcome were not significant, hence tilt test can be considered as necessary in the diagnosis of vasovagal syndrome.
心率（HR）、收缩压（sBP）、舒张压（dBP）和每搏输出量（SV），这些参数是在头高位倾斜试验（HUTT）期间对HUT试验结果为阳性和阴性的患者进行测量的。在PubMed和Clinical Key数据库中搜索仅用英文发表的关于晕厥患者倾斜试验期间生物信号测量结果的文章。从3289篇文章中，选取了1997年至2015年发表的13篇文章，这些文章研究了892例患者（467例HUTT结果为阳性，401例为阴性）。试验结果为阳性和阴性的患者在仰卧位测量的参数之间未观察到统计学上的显著差异[心率（P = 0.86）、收缩压（P = 0.32）、舒张压（P = 0.21）、每搏输出量（P = 0.71）]。在倾斜位时，两组患者相比，心率和每搏输出量参数有显著差异[心率（P = 0.02）、收缩压（P = 0.10）、舒张压（P = 0.59）、每搏输出量（P = 0.0004）]。结果表明，心率和每搏输出量参数对倾斜试验的反应具有统计学意义。在仰卧位时，试验结果为阳性和阴性的患者之间的差异不显著，因此倾斜试验可被认为是诊断血管迷走性晕厥综合征的必要手段。
