血清维生素D缺乏与妊娠期糖尿病风险：一项荟萃分析。
Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis.
作者信息
Wang Lanling, Zhang Chunlei, Song Yuhuan, Zhang Zhennan
机构信息
Maternity Department, W.F. Maternity and Child Care Hospital, Weicheng District, China.
Neonatology Department, Weifang Medical University, Weicheng District, China.
出版信息
Arch Med Sci. 2020 Apr 15;16(4):742-751. doi: 10.5114/aoms.2020.94433. eCollection 2020.
INTRODUCTION
This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D.
MATERIAL AND METHODS
PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed.
RESULTS
The vitamin D level of GDM subjects was much lower than healthy subjects (SMD = -0.71, 95% CI: -0.91, -0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07-1.23). Vitamin D was negatively correlated with HOMA-IR ( = -0.62, 95% CI: -0.85, -0.39). The analysis showed no publication bias (Egger's: = 0.197; Begg's: = 0.786).
CONCLUSIONS
Vitamin D is closely associated with the onset of GDM.
引言
本荟萃分析旨在证实妊娠期糖尿病（GDM）与维生素D之间的关系。
材料与方法
检索PubMed和CNKI数据库中的相关文章。采用标准均数差（SMD）及95%置信区间（CI）比较GDM女性与健康受试者的维生素D水平。分析维生素D与稳态模型评估胰岛素抵抗指数（HOMA-IR）之间的相关系数。
结果
GDM受试者的维生素D水平远低于健康受试者（SMD = -0.71，95% CI：-0.91，-0.50）。维生素D缺乏与GDM的高风险相关（OR = 1.15，95% CI：1.07 - 1.23）。维生素D与HOMA-IR呈负相关（ = -0.62，95% CI：-0.85，-0.39）。分析显示无发表偏倚（Egger检验： = 0.197；Begg检验： = 0.786）。
结论
维生素D与GDM的发病密切相关。
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