Qu Haiou, Jiang Weifeng, Wang Yongxu, Chen Peng
Department of Thyroid and Breast Surgery, The First People's Hospital of Wenling Wenling 317500, China.
Department of Surgery, The First People's Hospital of Wenling Wenling 317500, China.
Am J Transl Res. 2019 Feb 15;11(2):683-695. eCollection 2019.
STOML2 (Stomatin-like protein 2) is up-regulated and acts as an oncogenic protein in multiple cancers. However, the role and regulatory mechanism of STOML2 in head and neck squamous cell carcinoma remain unclear. Here, we found that STOML2 is overexpressed and indicates poor outcomes in HNSCC. In addition, the expression of STOML2 correlates positively with T stage, lymph node metastasis and recurrence. Reduced STOML2 dramatically inhibits cell proliferation, colony formation and motility of HNSCC cells . Furthermore, the sensitivity of HNSCC cells towards cisplatin is obviously improved in STOML2-silencing cells. Subsequent studies suggest that STOML2 could regulate the expression of IL6 transcriptionally and then further induce the phosphorylation of Tyr705 residue of Stat3, whose activation plays a critical role in HNSCC. Taken together, these results for the first time demonstrate that STOML2 promotes HNSCC progression through activating IL6-Stat3 pathway and provide a promise for diagnosis and treatment for HNSCC.
STOML2（类stomatin蛋白2）在多种癌症中上调并作为一种致癌蛋白发挥作用。然而，STOML2在头颈部鳞状细胞癌中的作用和调控机制仍不清楚。在此，我们发现STOML2在头颈部鳞状细胞癌中过表达且提示预后不良。此外，STOML2的表达与T分期、淋巴结转移和复发呈正相关。STOML2表达降低显著抑制头颈部鳞状细胞癌细胞的增殖、集落形成和迁移。此外，在STOML2沉默的细胞中，头颈部鳞状细胞癌细胞对顺铂的敏感性明显提高。后续研究表明，STOML2可转录调控IL6的表达，进而进一步诱导Stat3第705位酪氨酸残基的磷酸化，其激活在头颈部鳞状细胞癌中起关键作用。综上所述，这些结果首次证明STOML2通过激活IL6-Stat3通路促进头颈部鳞状细胞癌进展，并为头颈部鳞状细胞癌的诊断和治疗提供了希望。
