类stomatin蛋白2的表达与宫颈癌患者的临床生存期相关。
Stomatin-like protein 2 expression is associated with clinical survival in patients with cervical cancer.
作者信息
Xiao Binmei, Xie Zhiyi, Guo Lan, Wu Jianchi, Zhang Hongwen
机构信息
Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
Department of Gynaecology and Obstetrics, The Second Xiangya Hospital Central South University Changsha, HN 410011, China.
出版信息
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1804-9. eCollection 2015.
AIMS
To investigate the prognostic role of stomatin-like protein 2 (STOML2) in cervical cancer.
METHODS
The expression of STOML2 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR. Immunohistochemistry was performed to evaluation of STOML2 expression in 94 paraffin-embedded cervical cancer samples. The correlation between STOML2 expression and cervical cancer progression and prognosis was analyzed statistically.
RESULTS
STOML2 expression was upregulated in cervical cancer tissues compared with adjacent normal cervical tissues. Of the 94 cervical cancer cases, high STOML2 expression was detected in 54 cases (57.4%). STOML2 expression was significantly related to tumor stage (P = 0.013) and tumor size (P = 0.025). Moreover, patients with high expression of STOML2 had a significant shorter overall survival and recurrent free survival time compared with those with low STOML2 expression in cervical cancer (P = 0.001 and P = 0.017, respectively). Multivariate analysis revealed that STOML2 was an independent prognostic factor (P = 0.022) for the overall survival in cervical cancer.
CONCLUSION
Our study showed STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer.
目的
探讨类stomatin蛋白2（STOML2）在宫颈癌中的预后作用。
方法
采用实时荧光定量PCR检测8对宫颈癌组织及癌旁正常宫颈组织中STOML2的表达。采用免疫组织化学法评估94例石蜡包埋宫颈癌样本中STOML2的表达。对STOML2表达与宫颈癌进展及预后的相关性进行统计学分析。
结果
与癌旁正常宫颈组织相比，宫颈癌组织中STOML2表达上调。在94例宫颈癌病例中，54例（57.4%）检测到高STOML2表达。STOML2表达与肿瘤分期（P = 0.013）和肿瘤大小（P = 0.025）显著相关。此外，与宫颈癌中STOML2低表达的患者相比，STOML2高表达的患者总生存期和无复发生存期显著缩短（分别为P = 0.001和P = 0.017）。多因素分析显示，STOML2是宫颈癌总生存期的独立预后因素（P = 0.022）。
结论
我们的研究表明STOML2与宫颈癌进展相关，并提示其可能是宫颈癌预后的潜在预测因素。
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