Research Institute for Nutrition Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan.
BMJ Open Diabetes Res Care. 2019 Feb 7;7(1):e000596. doi: 10.1136/bmjdrc-2018-000596. eCollection 2019.
To examine whether serum adiponectin and orosomucoid were associated with postload glucose ≤70 mg/dL during an oral glucose tolerance test (OGTT), termed as postload low glycemia, a possible inverse marker for dysglycemia.
75 g OGTTs were performed with multiple postload glucose and insulin measurements over a 30-120 min period in 168 normal-weight Japanese women (18-24 years). Insulin resistance (IR) and β-cell function inferred from serum insulin kinetics during OGTT, fat mass and distribution by dual-energy X-ray absorptiometry (DXA), serum adiponectin and inflammatory markers were compared cross-sectionally between 39 women with and 129 women without postload low glycemia.
Of 168 women, 161 had normal glucose tolerance. Women with as compared with those without postload low glycemia had lower fasting and postload glycemia despite similar fasting and postload insulinemia. They had higher insulinogenic index (p=0.03) and lower adipose IR (a product of fasting free fatty acid and insulin, p=0.01), although DXA-derived general and central adiposity, the Matsuda Index and homeostasis model assessment-IR did not differ. In addition, they had higher adiponectin and lower orosomucoid (both p<0.001). Multivariate logistic regression analyses revealed that adiponectin (OR: 1.14, 95% CI 1.03 to 1.26, p=0.009) and orosomucoid (0.96, 0.93 to 0.97, p=0.008) were associated with postload low glycemia independently of adipose IR and insulinogenic index.
Higher adiponectin and lower orosomucoid were associated with 70 or lower mg/dL of postload glucose, a possible inverse marker for dysglycemia, in young women independently of DXA-derived fat mass and distribution, insulin secretion and IR.
研究血清脂联素和触珠蛋白是否与口服葡萄糖耐量试验（OGTT）后的负荷后血糖≤70mg/dL（称为负荷后低血糖）相关，这可能是血糖异常的一个反向标志物。
对 168 名日本正常体重女性（18-24 岁）进行 75g OGTT，并在 30-120 分钟期间进行多次负荷后血糖和胰岛素测量。使用双能 X 射线吸收法（DXA）对脂肪量和分布进行评估，比较 39 名负荷后低血糖女性和 129 名无负荷后低血糖女性在 OGTT 期间血清胰岛素动力学推断的胰岛素抵抗（IR）和β细胞功能、血清脂联素和炎症标志物的横断面差异。
在 168 名女性中，161 名女性糖耐量正常。与无负荷后低血糖的女性相比，有负荷后低血糖的女性尽管空腹和负荷后胰岛素水平相似，但空腹和负荷后血糖水平较低。她们的胰岛素生成指数更高（p=0.03），脂肪组织 IR 更低（空腹游离脂肪酸和胰岛素的乘积，p=0.01），尽管 DXA 衍生的全身和中心性肥胖、Matsuda 指数和稳态模型评估的胰岛素抵抗没有差异。此外，她们的脂联素水平更高，而触珠蛋白水平更低（均<0.001）。多变量逻辑回归分析显示，脂联素（OR：1.14，95%CI 1.03 至 1.26，p=0.009）和触珠蛋白（0.96，0.93 至 0.97，p=0.008）与负荷后低血糖独立相关，不受脂肪组织 IR 和胰岛素生成指数的影响。
在年轻女性中，较高的脂联素和较低的触珠蛋白与 70mg/dL 或更低的负荷后血糖相关，这可能是血糖异常的一个反向标志物，独立于 DXA 衍生的脂肪量和分布、胰岛素分泌和 IR。
