经颅磁刺激疗法治疗局灶性腿部肌张力障碍：一例报告
Transcranial magnetic stimulation therapy for focal leg dystonia: a case report.
作者信息
Sharma Kush, Cucca Alberto, Lee Andrea, Agarwal Shashank, Frucht Steven Joel, Biagioni Milton Cesar
机构信息
1The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, NYU School of Medicine, 222 E 41st Street, 13th Floor, New York, NY 10017 USA.
2Present address: Parkinson's Disease & Movement Disorders Institute, at Weill Cornell Medicine, New York, NY USA.
出版信息
J Clin Mov Disord. 2019 Mar 8;6:1. doi: 10.1186/s40734-019-0076-z. eCollection 2019.
BACKGROUND
Dystonia is a debilitating disease that causes abnormal, often repetitive, movements, postures or both. The pathophysiology is unknown but related to loss of neuronal inhibition, aberrant sensorimotor integration, and/or derangements of synaptic plasticity. Current treatments include pharmacotherapy, botulinum toxin injections and deep brain stimulation (DBS). The response to these treatments are often limited and carry the risk of side effects requiring alternative therapies such as non-invasive brain stimulation.
CASE PRESENTATION
We present a case report of a 65-year -old man with refractory focal 'task-specific' dystonia. The treatment plan included 10-daily sessions of 1 Hz, 2600 pulses of repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex.
CONCLUSION
There were no clinical benefits noticed. Currently, there are no rTMS protocol treatments for dystonia. Publication of negative results will help in refining the optimal stimulation parameters, thus maximizing the effectiveness and reproducibility of future therapeutic protocols.
背景
肌张力障碍是一种使人衰弱的疾病，会导致异常的、通常是重复性的运动、姿势或两者皆有。其病理生理学尚不清楚，但与神经元抑制丧失、感觉运动整合异常和/或突触可塑性紊乱有关。目前的治疗方法包括药物治疗、肉毒杆菌毒素注射和深部脑刺激（DBS）。这些治疗方法的效果往往有限，且有副作用风险，因此需要非侵入性脑刺激等替代疗法。
病例报告
我们报告一例65岁患有难治性局灶性“任务特异性”肌张力障碍的男性病例。治疗方案包括针对初级运动皮层进行为期10天、每天1次、频率为1赫兹、2600个脉冲的重复经颅磁刺激（rTMS）。
结论
未观察到临床益处。目前，尚无针对肌张力障碍的rTMS方案治疗。发表阴性结果将有助于完善最佳刺激参数，从而使未来治疗方案的有效性和可重复性最大化。
Zotero 插件