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药物治疗在股骨头坏死的预防或治疗中是否发挥作用？一项系统评价

Is There a Role of Pharmacological Treatments in the Prevention or Treatment of Osteonecrosis of the Femoral Head?: A Systematic Review.

作者信息

Lee Yun Jong, Cui Quanjun, Koo Kyung-Hoi

机构信息

Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA.

出版信息

J Bone Metab. 2019 Feb;26(1):13-18. doi: 10.11005/jbm.2019.26.1.13. Epub 2019 Feb 28.

DOI:10.11005/jbm.2019.26.1.13
PMID:30899719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6416144/
Abstract

BACKGROUND

Various pharmacological treatments have been suggested to treat osteonecrosis of the femoral head. However, their practicability remains a controversial issue.

METHODS

We systemically reviewed articles published during last 20 years to assess the efficacy and safety of the pharmacological treatments.

RESULTS

To date, enoxaparin, statins, bisphosphonates, iloprost and acetylsalicylic acid have been practiced for the treatment of osteonecrosis. However, none of them were proven to be effective by high level studies, and most of them have adverse reactions.

CONCLUSIONS

No pharmacological prevention or treatment of osteonecrosis is recommendable at this moment.

摘要

背景

已提出多种药物治疗方法用于治疗股骨头坏死。然而，它们的实用性仍然是一个有争议的问题。

方法

我们系统回顾了过去20年发表的文章，以评估药物治疗的疗效和安全性。

结果

迄今为止，依诺肝素、他汀类药物、双膦酸盐、伊洛前列素和乙酰水杨酸已用于治疗骨坏死。然而，没有一项经过高水平研究证明是有效的，并且它们中的大多数都有不良反应。

结论

目前不推荐使用任何药物预防或治疗骨坏死。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/6416144/a087eeba0a15/jbm-26-13-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/6416144/a087eeba0a15/jbm-26-13-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/6416144/a087eeba0a15/jbm-26-13-g001.jpg

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