[不同单细胞结构骨支架设计的研究进展]
[Research progress on the design of bone scaffolds with different single cell structures].
作者信息
Sun Yadi, Wang Yan, Zhou Liyun, Li Yiyang, Shen Jiahui, Dong Benchao, Yang Peichuan, Li Yan, Ma Jianxiong, Ma Xinlong
机构信息
Institute of Orthopaedics, Tianjin Hospital, Tianjin University (Tianjin Hospital), Tianjin, 300211, P. R. China.
Tianjin Orthopedic Institute, Tianjin, 300050, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Aug 15;37(8):1037-1041. doi: 10.7507/1002-1892.202303130.
OBJECTIVE
To review the research progress of design of bone scaffolds with different single cell structures.
METHODS
The related literature on the study of bone scaffolds with different single cell structures at home and abroad in recent years was extensively reviewed, and the research progress was summarized.
RESULTS
The single cell structure of bone scaffold can be divided into regular cell structure, irregular cell structure, cell structure designed based on topology optimization theory, and cell structure designed based on triply periodic minimal surface. Different single cell structures have different structural morphology and geometric characteristics, and the selection of single cell structure directly determines the mechanical properties and biological properties of bone scaffold. It is very important to choose a reasonable cell structure for bone scaffold to replace the original bone tissue.
CONCLUSION
Bone scaffolds have been widely studied, but there are many kinds of bone scaffolds at present, and the optimization of single cell structure should be considered comprehensively, which is helpful to develop bone scaffolds with excellent performance and provide effective support for bone tissue.
目的
综述不同单胞结构骨支架设计的研究进展。
方法
广泛查阅近年来国内外关于不同单胞结构骨支架研究的相关文献，并总结研究进展。
结果
骨支架的单胞结构可分为规则孔结构、不规则孔结构、基于拓扑优化理论设计的孔结构以及基于三周期极小曲面设计的孔结构。不同的单胞结构具有不同的结构形态和几何特征，单胞结构的选择直接决定了骨支架的力学性能和生物学性能。为骨支架选择合理的孔结构以替代原始骨组织非常重要。
结论
骨支架已得到广泛研究，但目前骨支架种类繁多，应综合考虑单胞结构的优化，这有助于开发性能优异的骨支架并为骨组织提供有效支撑。
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