Reinke Rasmus H, Larsen Stine R, Mathiesen Jes S, Godballe Christian, Londero Stefano C
Department of ORL - Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.
Department of ORL - Head & Neck Surgery and Audiology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Head Neck Pathol. 2020 Mar;14(1):144-149. doi: 10.1007/s12105-019-01032-2. Epub 2019 Mar 21.
The renaming of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was proposed by a group of experts in 2016 to prevent overtreatment of indolent, low-risk thyroid cancers. The aim of this study was to estimate the incidence and outcome for patients meeting the NIFTP criteria in a well-defined geographic region. Our cohort consisted of 134 patients with papillary thyroid carcinoma from the Region of Southern Denmark (RSD), 2007 to 2011. Patients were retrieved from the Danish Thyroid Cancer (DATHYRCA) Database. All potential NIFTP cases were reviewed by a thyroid pathologist. We identified no cases meeting all diagnostic criteria, but one probable NIFTP case from 2007 to 2011. The patient was treated according to the national guidelines and is alive and recurrence-free after 106 months of follow-up. Molecular testing showed KRAS mutation. In a population based set up the incidence rate of NIFTP is very low.
2016年，一组专家提议将甲状腺乳头状癌的包膜内滤泡型变体（EFVPTC）重新命名为具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP），以避免对惰性、低风险甲状腺癌进行过度治疗。本研究的目的是评估在一个明确的地理区域内符合NIFTP标准的患者的发病率和转归。我们的队列包括2007年至2011年来自丹麦南部地区（RSD）的134例甲状腺乳头状癌患者。患者数据来自丹麦甲状腺癌（DATHYRCA）数据库。所有可能的NIFTP病例均由甲状腺病理学家进行复查。我们未发现符合所有诊断标准的病例，但在2007年至2011年期间发现了1例可能的NIFTP病例。该患者按照国家指南接受了治疗，在随访106个月后仍存活且无复发。分子检测显示存在KRAS突变。在基于人群的研究中，NIFTP的发病率非常低。
