British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Centre for Research in Exercise Physiology (CIFE), Universidad Mayor, Santiago, Chile.
Obesity (Silver Spring). 2019 Apr;27(4):653-661. doi: 10.1002/oby.22417.
This study aimed to investigate whether the association between a validated genetic profile risk score for BMI (GPRS-BMI) (based on 93 single-nucleotide polymorphisms) and phenotypic obesity (BMI) was modified by the combined categories of physical activity (PA) and sedentary behaviors in a large population-based study.
This study included cross-sectional baseline data from 338,216 white European adult men and women aged 37 to 73 years. Interaction effects of GPRS-BMI with the combined categories of PA and sedentary behaviors on BMI were investigated.
There was a significant interaction between GPRS-BMI and the combined categories of objectively measured PA and total sedentary behavior (P = 3.5 × 10 ); among physically inactive and highly sedentary individuals, BMI was higher by 0.60 kg/m per 1-SD increase in GPRS-obesity (P = 8.9 × 10 ), whereas the relevant BMI difference was 38% lower among physically active individuals and those with low sedentary time (β: 0.37 kg/m ; P = 2.3 × 10 ). A similar pattern was observed for the combined categories of objective PA and TV viewing (inactive/high TV viewing β: 0.60 vs. active/low TV viewing β: 0.40 kg/m ; P = 2.9 × 10 ).
This study provides evidence that combined categories of PA and sedentary behaviors modify the extent to which genetic predisposition to obesity results in higher BMI.
本研究旨在探讨基于 93 个单核苷酸多态性的 BMI 验证遗传风险评分（GPRS-BMI）与表型肥胖（BMI）之间的关联是否受到基于大人群的研究中体力活动（PA）和久坐行为综合类别的影响。
本研究纳入了 338216 名年龄在 37 至 73 岁的白种欧洲成年男性和女性的横断面基线数据。研究调查了 GPRS-BMI 与 PA 和久坐行为综合类别的交互效应对 BMI 的影响。
GPRS-BMI 与客观测量的 PA 和总久坐行为的综合类别之间存在显著的交互作用（P = 3.5×10）；在非活跃和高度久坐的个体中，GPRS 肥胖每增加 1-SD，BMI 升高 0.60 kg/m（P = 8.9×10），而在活跃的个体和久坐时间较短的个体中，相关的 BMI 差异降低了 38%（β：0.37 kg/m；P = 2.3×10）。对于客观 PA 和电视观看的综合类别，也观察到了类似的模式（非活跃/高电视观看β：0.60 vs. 活跃/低电视观看β：0.40 kg/m；P = 2.9×10）。
本研究提供了证据表明，PA 和久坐行为的综合类别改变了肥胖遗传易感性导致更高 BMI 的程度。
