聚合物 DNA 纳米粒的尺寸控制合成及其用于靶向抗癌药物递送。
Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery.
机构信息
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
出版信息
Chem Commun (Camb). 2019 Apr 23;55(34):4905-4908. doi: 10.1039/c9cc01442j.
PMID:30901006
Abstract
We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.
摘要
我们通过滚环扩增、缩合和层层组装的顺序过程合成了可尺寸调谐的聚合 DNA 纳米颗粒（PDN），用于癌症靶向药物传递。PDN 选择性地将反义寡核苷酸递送至靶癌细胞，并表现出尺寸依赖性的基因调控功效。
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