Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Queensland, 4072, Australia.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, St. Lucia, Queensland, 4072, Australia.
Angew Chem Int Ed Engl. 2019 Oct 1;58(40):14357-14364. doi: 10.1002/anie.201908357. Epub 2019 Aug 19.
A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10 % or even 1 %. Now, core-shell nanoparticles are fabricated having exceptionally high drug loading up to 65 % (drug weight/the total weight of drug-loaded nanoparticles) and high encapsulation efficiencies (>99 %) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug-core silica-shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug-loading nanoparticles.
已经开发出了大量的纳米粒子来包裹疏水性药物。然而，药物负载通常小于 10%，甚至 1%。现在，基于模块化生物分子模板，制备了具有极高药物负载（药物重量/载药纳米粒子的总重量）和高包封效率（>99%）的核壳纳米粒子。设计双功能两亲肽不仅可以稳定疏水性药物纳米粒子，还可以在纳米药物颗粒表面诱导生物硅化，从而形成药物-核二氧化硅-壳纳米复合材料。该平台技术对于封装各种疏水性载药具有高度的通用性。此外，高药物负载纳米粒子导致更好的体外细胞毒性作用和体内肿瘤生长抑制，突出了使用高药物负载纳米粒子的重要性。
