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使用虚拟现实显示器的便携式神经光学诊断系统。

Portable System for Neuro-Optical Diagnostics Using Virtual Reality Display.

作者信息

Versek Craig, Rissmiller Armen, Tran Anthony, Taya Munish, Chowdhury Kaushik, Bex Peter, Sridhar Srinivas

机构信息

NeuroFieldz Inc, 41 Esty Farm Road, Newton, MA.

Department of Physics, Northeastern University, 110 Forsyth St., 111 Dana Research Center, Boston, MA.

出版信息

Mil Med. 2019 Mar 1;184(Suppl 1):584-592. doi: 10.1093/milmed/usy286.

DOI:10.1093/milmed/usy286
PMID:30901414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6433097/
Abstract

A new product prototype system for diagnosing vision and neurological disorders, called NeuroDotVR, is described herein: this system utilizes a novel wireless NeuroDot brain sensor [Versek C et al. J Neural Eng. 2018 Aug; 15(4):046027] that quantitatively measures visual evoked potentials and fields resulting from custom visual stimuli displayed on a smartphone housed in a virtual reality headset. The NeuroDot brain sensor is unique in that it can be operated both in regular electroencephalography mode, as well as a new electric field encephalography mode, which yields improvements in signal sensitivity and provides new diagnostic information. Steady state and transient visual evoked potentials and fields using reversing checkerboard stimuli are presented with case studies in amblyopia, glaucoma, and dark adaptation. These preliminary data sets highlight potential clinical applications that may be pursued in further product development and scientific studies.

摘要

本文介绍了一种名为NeuroDotVR的用于诊断视力和神经疾病的新产品原型系统:该系统利用一种新型无线NeuroDot脑传感器[Versek C等人,《神经工程学杂志》,2018年8月;15(4):046027],该传感器可定量测量由虚拟现实头戴式设备中智能手机上显示的定制视觉刺激所产生的视觉诱发电位和视野。NeuroDot脑传感器的独特之处在于它既可以在常规脑电图模式下操作,也可以在新的电场脑电图模式下操作,后者可提高信号灵敏度并提供新的诊断信息。本文通过弱视、青光眼和暗适应的案例研究,展示了使用反转棋盘格刺激的稳态和瞬态视觉诱发电位及视野。这些初步数据集突出了在进一步的产品开发和科学研究中可能探索的潜在临床应用。

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本文引用的文献

1
Electric field encephalography for brain activity monitoring.电场脑电图用于脑活动监测。
J Neural Eng. 2018 Aug;15(4):046027. doi: 10.1088/1741-2552/aac3f9. Epub 2018 May 11.
2
Very high density EEG elucidates spatiotemporal aspects of early visual processing.超高密度脑电图揭示了早期视觉处理的时空方面。
Sci Rep. 2017 Nov 24;7(1):16248. doi: 10.1038/s41598-017-16377-3.
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Binocular Therapy for Childhood Amblyopia Improves Vision Without Breaking Interocular Suppression.儿童弱视的双眼疗法可改善视力且不打破双眼抑制。
Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3031-3043. doi: 10.1167/iovs.16-20913.
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Chronic visual dysfunction after blast-induced mild traumatic brain injury.爆炸所致轻度创伤性脑损伤后的慢性视觉功能障碍
J Rehabil Res Dev. 2014;51(1):71-80. doi: 10.1682/JRRD.2013.01.0008.
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Ultra-dense EEG sampling results in two-fold increase of functional brain information.超密集脑电图采样使大脑功能信息增加了两倍。
Neuroimage. 2014 Apr 15;90:140-5. doi: 10.1016/j.neuroimage.2013.12.041. Epub 2014 Jan 4.
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Electric Field Encephalography as a tool for functional brain research: a modeling study.电场脑图作为功能脑研究的工具:一项建模研究。
PLoS One. 2013 Jul 3;8(7):e67692. doi: 10.1371/journal.pone.0067692. Print 2013.
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Objective diagnostic and interventional vision test protocol for the mild traumatic brain injury population.针对轻度创伤性脑损伤人群的客观诊断和介入性视力测试方案。
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A game platform for treatment of amblyopia.弱视治疗游戏平台。
IEEE Trans Neural Syst Rehabil Eng. 2011 Jun;19(3):280-9. doi: 10.1109/TNSRE.2011.2115255. Epub 2011 Feb 17.
9
Visual dysfunction following blast-related traumatic brain injury from the battlefield.战场上与爆炸相关的创伤性脑损伤后的视觉功能障碍。
Brain Inj. 2011;25(1):8-13. doi: 10.3109/02699052.2010.536195. Epub 2010 Nov 30.
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Steady-state visually evoked potentials: focus on essential paradigms and future perspectives.稳态视觉诱发电位:聚焦基本范式和未来展望。
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