Versek Craig, Banijamali S Mohammad Ali, Bex Peter, Lashkari Kameran, Kamarthi Sagar, Sridhar Srinivas
NeuroFieldz Inc, Newton, MA, USA.
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Eye Brain. 2021 Apr 29;13:111-127. doi: 10.2147/EB.S295745. eCollection 2021.
Delayed Dark-Adapted vision Recovery (DAR) is a biomarker for Age-related Macular Degeneration (AMD), however its measurement is burdensome for patients and examiners.
In this study, we developed a portable, wireless and user-friendly system that employs a headset with a smartphone to deliver controlled photo-bleach and monocular pattern reversal stimuli, while using custom electroencephalography (EEG) electrodes and electronics in order to measure Dark-Adapted Visual Evoked Potentials (DAVEP) objectively and separately at the peripheral and central visual field. This is achieved in one comfortable 20-minute session, without requiring subject reporting. DAVEP responses post photo-bleach for up to 15 minutes were measured concurrently from both eyes in 12 AMD-patients, 1 degenerative myopia patient, and 8 controls who had no diagnosed macular vision loss.
Robust positive polarity DAVEP responses were observed at 200-500 ms from stimulus onset to scotopic stimuli that have been seldom reported and analyzed previously. The amplitude recovery of the DAVEP response was significantly delayed in AMD patients as compared to controls. We developed DAVEP1 scores, a simple metric for DAR, which classified 90% of subject eyes correctly, indicating the presence of AMD in at least one eye of all pre-confirmed subjects with this diagnosis.
We developed a user-friendly, portable VEP system and DAVEP1 metric, which show a high potential to identify DAR-deficits in AMD-patients. This novel technology could aid in early diagnosis of AMD.
延迟暗适应视觉恢复（DAR）是年龄相关性黄斑变性（AMD）的一种生物标志物，然而其测量对患者和检查者来说都很繁琐。
在本研究中，我们开发了一种便携式、无线且用户友好的系统，该系统采用带有智能手机的头戴式设备来提供可控的光漂白和单眼模式反转刺激，同时使用定制的脑电图（EEG）电极和电子设备，以便在外周和中心视野客观且分别地测量暗适应视觉诱发电位（DAVEP）。这在一次舒适的20分钟检查中即可完成，无需受试者报告。在12名AMD患者、1名退行性近视患者和8名未诊断出黄斑视力丧失的对照者中，同时测量了两只眼睛在光漂白后长达15分钟的DAVEP反应。
在刺激开始后200 - 500毫秒时，观察到对暗视刺激有强烈的正极性DAVEP反应，此前很少有报道和分析。与对照组相比，AMD患者中DAVEP反应的幅度恢复明显延迟。我们开发了DAVEP1评分，这是一种用于DAR的简单指标，能正确分类90%的受试者眼睛，表明所有预先确诊为此诊断的受试者中至少有一只眼睛存在AMD。
我们开发了一种用户友好的便携式VEP系统和DAVEP1指标，它们在识别AMD患者的DAR缺陷方面显示出很高的潜力。这项新技术有助于AMD的早期诊断。
