Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, 3131 Harvey Avenue, Suite 104, Cincinnati, OH, 45229, USA.
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, MSC861, Charleston, SC, 29425, USA.
Drug Alcohol Depend. 2019 May 1;198:105-111. doi: 10.1016/j.drugalcdep.2019.01.041. Epub 2019 Mar 14.
Despite the high prevalence of blunt smoking among cannabis users, very few studies examine the clinical profile of blunt smokers relative to those using more common methods of cannabis use, such as joints.
The current study uses baseline data from the ACCENT (Achieving Cannabis Cessation-Evaluating N-acetylcysteine Treatment) study, a multi-site randomized pharmacotherapy clinical trial within the National Drug Abuse Treatment Clinical Trials Network, to predict the association between blunt and joint use frequency and cannabis use characteristics (e.g., grams of cannabis used) and consequences (e.g., withdrawal) among past-month cannabis users (N = 377) who were screened for study participation.
After controlling for race, age, gender, other forms of cannabis use (including joint use) and nicotine dependence, multivariable linear regression models indicated that the number of days of blunt use in the past month was a significant predictor of the average amount of cannabis per using day (t = 3.04, p < .01), the estimated average cost of cannabis (t = 2.28, p < .05) and Cannabis Withdrawal Scale scores (t = 1.94, p < .05). Frequency of joint use did not significantly predict any of the cannabis use characteristics or consequences.
Blunt smokers may present to treatment with greater amounts of cannabis smoked and more intense withdrawal symptoms, which may adversely impact their likelihood of successful abstinence. Cannabis-dependent blunt smokers may be more likely to benefit from treatment that targets physiological and mood-related withdrawal symptoms.
尽管吸食大麻的人中有很高比例的人吸食大麻烟，但很少有研究考察吸食大麻烟者与那些使用更常见的大麻使用方法（如大麻卷烟）者的临床特征的关系。
本研究使用了 ACCENT（实现大麻戒断-评估 N-乙酰半胱氨酸治疗）研究的基线数据，该研究是国家药物滥用治疗临床试验网络中的一个多地点随机药物治疗临床试验，旨在预测大麻烟和大麻卷烟使用频率与大麻使用特征（例如，使用的大麻克数）和后果（例如，戒断）之间的关联，研究对象为过去一个月有大麻使用史且符合研究入组条件的参与者（N=377）。
在控制了种族、年龄、性别、其他形式的大麻使用（包括大麻卷烟使用）和尼古丁依赖后，多变量线性回归模型表明，过去一个月中吸食大麻烟的天数是大麻日使用量平均值（t=3.04，p<.01）、大麻估计平均消费（t=2.28，p<.05）和大麻戒断量表得分（t=1.94，p<.05）的显著预测因子。大麻卷烟使用频率并未显著预测任何大麻使用特征或后果。
吸食大麻烟者可能会在治疗中呈现出更高的大麻吸食量和更强烈的戒断症状，这可能会对他们成功戒断的可能性产生不利影响。依赖吸食大麻烟者可能更受益于针对生理和情绪相关戒断症状的治疗。
