Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), ISCIII, 28029 Madrid, Spain.
Nutrients. 2019 Mar 21;11(3):677. doi: 10.3390/nu11030677.
Non-alcoholic fatty liver disease (NAFLD) is a major global health threat due to its growing incidence and prevalence. It is becoming the leading cause of liver disease in addition to its strong association with cardio-metabolic disease. Therefore, its prevention and treatment are of strong public interest. Therapeutic approaches emphasize lifestyle modifications including physical activity and the adoption of healthy eating habits that intend to mainly control body weight and cardio-metabolic risk factors associated with the metabolic syndrome. Lifestyle interventions may be reinforced by pharmacological treatment in advanced stages, though there is still no registered drug for the specific treatment of NAFLD. The purpose of this review is to assess the evidence available regarding the impact of dietary recommendations against NAFLD, highlighting the effect of macronutrient diet composition and dietary patterns in the management of NAFLD.
非酒精性脂肪性肝病（NAFLD）是一个主要的全球健康威胁，因为它的发病率和患病率不断增加。除了与心血管代谢疾病密切相关外，它还成为了导致肝脏疾病的主要原因。因此，预防和治疗该病具有很强的公共利益。治疗方法强调生活方式的改变，包括体育活动和采用健康的饮食习惯，主要目的是控制体重和与代谢综合征相关的心血管代谢危险因素。在疾病的晚期阶段，生活方式干预可能会通过药物治疗来加强，尽管目前还没有专门用于治疗 NAFLD 的注册药物。本综述的目的是评估关于饮食建议对 NAFLD 影响的现有证据，重点介绍宏量营养素饮食成分和饮食模式在 NAFLD 管理中的作用。
