催乳素和催乳素诱导蛋白（PIP）在原发性获得性鼻泪管阻塞（PANDO）发病机制中的作用。
Prolactin and Prolactin-inducible protein (PIP) in the pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).
机构信息
Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Núrnberg, Germany; Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, India.
Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Núrnberg, Germany.
出版信息
Med Hypotheses. 2019 Apr;125:137-138. doi: 10.1016/j.mehy.2019.02.051. Epub 2019 Mar 1.
Primary acquired nasolacrimal duct obstruction (PANDO) is a syndrome of unknown etiology, predominantly affecting post-menopausal females, characterized by progressive inflammation, fibrosis and subsequent obstruction of the nasolacrimal duct. Numerous factors have been proposed as possible etiologic factors and include anatomical configuration, ocular and nasal infections, peri-lacrimal vascular disorders, hormonal influence, lacrimal drainage lymphoid tissue, gastroesophageal reflux disease, topical medications, swimming pool exposure, smoking, genetic factors, autonomic and lysosomal dysregulation. The authors hypothesize Prolactin (PRL) and Prolactin-inducible protein (PIP) play a role in the etiopathogenesis of primary acquired nasolacrimal duct obstruction.
原发性鼻泪管阻塞（PANDO）是一种病因不明的综合征，主要影响绝经后女性，其特征为进行性炎症、纤维化和随后的鼻泪管阻塞。许多因素被认为是可能的病因，包括解剖结构、眼部和鼻部感染、泪囊周围血管疾病、激素影响、泪液引流淋巴组织、胃食管反流病、局部用药、游泳池暴露、吸烟、遗传因素、自主和溶酶体失调。作者假设催乳素（PRL）和催乳素诱导蛋白（PIP）在原发性鼻泪管阻塞的发病机制中起作用。
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