Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary; Institute of Psychology, Eötvös Loránd University, Budapest, Hungary; Doctoral School of Psychology, Eötvös Loránd University, Budapest, Hungary.
Physiol Behav. 2019 Jul 1;206:28-36. doi: 10.1016/j.physbeh.2019.03.022. Epub 2019 Mar 19.
The current study investigated how experimentally induced acute normobaric hypoxia affects attentional control functions during easy, monotonous visual sustained attention and response inhibition (modified Continuous Performance Task) and executive control tasks (number-size Stroop task). Along with behavioral efficiency, task-relevant and task-irrelevant information processing were investigated by measuring event related brain potentials (ERP) evoked by target stimuli (Target P3), task-relevant stimuli with no response needed (NoGo P3), and task-irrelevant novel stimuli (Novelty P3) during acute hypoxia exposure. Normobaric hypoxia was induced by adjusting the O content of the breathing mixture to obtain 80% peripheral oxygen saturation, equivalent of 5500 m above sea level. Here we report decreased Novelty P3 during acute normobaric hypoxia exposure, while Target P3 and NoGo P3, as well as behavioral efficiency remained intact. Our paper is the first to provide evidence for impaired novelty processing along with intact task-relevant information processing and response inhibition during normobaric hypoxic exposure.
当前的研究调查了实验诱导的急性常压缺氧如何影响简单、单调的视觉持续注意力和反应抑制（改良的连续作业任务）以及执行控制任务（数字大小 Stroop 任务）期间的注意力控制功能。通过测量目标刺激（靶 P3）、无需反应的任务相关刺激（无反应 P3）和任务无关的新颖刺激（新颖 P3）诱发的事件相关脑电位（ERP），与行为效率一起，研究了与任务相关和与任务无关的信息处理。通过调整呼吸混合物中的 O 含量来诱导常压缺氧，以获得 80%的外周血氧饱和度，相当于海拔 5500 米以上。在这里，我们报告说在急性常压缺氧暴露期间，新颖性 P3 减少，而靶 P3 和无反应 P3 以及行为效率保持不变。我们的论文首次提供了证据，证明在常压缺氧暴露期间，与任务相关的信息处理和反应抑制完好无损的情况下，新奇处理受损。
