Danesh Arash, Gottschalk P Christopher H
Division of Headache Medicine, Department of Neurology, Yale University, LLCI 710F 15 York St., New Haven, CT, 06510, USA.
Curr Treat Options Neurol. 2019 Mar 23;21(4):20. doi: 10.1007/s11940-019-0556-3.
This review seeks to establish the role of beta-blockers (B-adrenergic receptor antagonists) in the pathophysiology of migraine prophylaxis, compare the efficacy of this group of medications with other common prophylactic agents, and also explore the relative benefits of using individual beta-blockers compared with others.
New evidence supports beta-blockers having several mechanisms of action in migraine prophylaxis. Numerous trials reveal significant clinical differences between various beta-blockers in migraine prophylaxis and that commonly used doses of beta-blockers are not optimal. There are also updated guidelines regarding beta-blocker use in migraine prophylaxis. Beta-blockers appear to have several mechanisms of action in migraine prophylaxis. We found extensive evidence supporting beta-blockers being effective in migraine prophylaxis. These are often not used at optimum doses; however, when they are, they compare generally favorably compared with other classes of medications. More recent evidence appears to show a relatively favorable side effect profile of beta-blockers compared with previous reports (Barron et al. IJC 163:3572-3579, 2013).
本综述旨在确立β受体阻滞剂（β肾上腺素能受体拮抗剂）在偏头痛预防病理生理学中的作用，比较该类药物与其他常用预防药物的疗效，并探讨使用不同β受体阻滞剂相较于其他药物的相对益处。
新证据支持β受体阻滞剂在偏头痛预防中有多种作用机制。大量试验表明，不同β受体阻滞剂在偏头痛预防方面存在显著临床差异，且β受体阻滞剂的常用剂量并非最佳。此外，还有关于β受体阻滞剂用于偏头痛预防的更新指南。β受体阻滞剂在偏头痛预防中似乎有多种作用机制。我们发现大量证据支持β受体阻滞剂对偏头痛预防有效。它们通常未以最佳剂量使用；然而，当以最佳剂量使用时，与其他类药物相比，总体效果通常较好。与先前报告相比，最新证据似乎显示β受体阻滞剂的副作用相对较好（Barron等人，《国际临床药理学杂志》163:3572 - 3579，2013年）。
