Department of Urology, Wake Forest Baptist Medical Center, Winston-Salem, NC, 27157-1094, USA.
Int Urol Nephrol. 2019 May;51(5):765-771. doi: 10.1007/s11255-019-02126-0. Epub 2019 Mar 22.
With the availability of near-infrared fluorescence (NIRF) imaging using indocyanine green dye (ICG) to the robotic platform, utility of this imaging technology has evolved significantly across the board for ablative and reconstructive procedures. Herein, we describe the potential indications of indocyanine green for both oncologic and non-oncologic applications in robot-assisted laparoscopic urologic surgery.
A narrative mini-review was performed in November 2018 using PubMed, Scopus, EMBASE, and Web of Science databases utilizing the following search phrase: "indocyanine green fluorescence robotic surgery" resulting in 104 articles of which 30 articles had urologic-pertinent applications. All 30 articles, and the references within, were reviewed and judged for scientific integrity and merit. Articles with non-novel findings or similar conclusions to original papers were omitted.
ICG does not have a urologic FDA indication, though it has been used off-label for urologic surgery since 2006. Fluorescence-augmented surgery with ICG can facilitate oncologic surgery in the adrenal gland, kidney, bladder, prostate, and retroperitoneum, in addition to lymph node dissection for various malignant pathologies. ICG-NIRF can enhance non-oncologic surgery including ureterolysis, ureteroureterostomy, ureteral re-implantation, pyeloplasty, and urinary diversion in both the adult and pediatric populations.
Although it is not necessary to utilize fluorescence-enhanced surgery in all cases, the authors find the utilization of ICG-NIRF in complex and highly technical surgeries useful.
随着近红外荧光（NIRF）成像技术的发展，吲哚菁绿染料（ICG）可应用于机器人平台，其在消融和重建手术中的应用也得到了广泛的发展。本文描述了吲哚菁绿在机器人辅助腹腔镜泌尿外科手术中治疗肿瘤和非肿瘤疾病的潜在适应证。
2018 年 11 月，我们使用 PubMed、Scopus、EMBASE 和 Web of Science 数据库，通过以下搜索词进行了叙述性迷你综述：“吲哚菁绿荧光机器人手术”，共检索到 104 篇文章，其中 30 篇文章与泌尿科相关。我们对所有 30 篇文章及其参考文献进行了回顾和评估，以判断其科学完整性和价值。我们忽略了没有新发现或与原始论文类似结论的文章。
ICG 尚未获得泌尿科 FDA 适应证，但自 2006 年以来已被用于泌尿科手术的适应证外使用。荧光增强手术中使用 ICG 可以辅助肾上腺、肾脏、膀胱、前列腺和腹膜后腔的肿瘤手术，以及各种恶性肿瘤的淋巴结清扫。ICG-NIRF 可增强非肿瘤手术，包括成人和儿童的输尿管松解术、输尿管-输尿管吻合术、输尿管再植术、肾盂成形术和尿流改道术。
虽然并非所有情况下都需要使用荧光增强手术，但作者认为在复杂和高难度手术中使用 ICG-NIRF 是有用的。
