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环境控制在管理低收入城市社区哮喘中的作用。

The Role of Environmental Controls in Managing Asthma in Lower-Income Urban Communities.

机构信息

Division of Pulmonology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168th Street, 11th floor, New York, NY, 10032, USA.

出版信息

Clin Rev Allergy Immunol. 2019 Dec;57(3):391-402. doi: 10.1007/s12016-019-08727-y.

Abstract

Children living in lower-income urban communities are at much greater risk of developing asthma, going to the emergency department for an asthma attack and being hospitalized for asthma than children living in upper- and middle-income communities. For many asthmatic children living in urban communities, especially those with greater morbidity, the allergic pathway is important in the etiology of the disease. The stages of developing allergic disease can be divided into the onset of allergic sensitization, development of allergic disease and subsequent exacerbations, and it is useful to consider the relevance of interventions at each of these stages. Indoor allergens and environmental exposures are a major contributor to allergic disease, particularly among lower socioeconomic status, urban, minority communities. These exposures include allergens, environmental tobacco smoke, combustion by-products, and mold, all of which can play an important role in asthma progression as well as morbidity. These exposures are often not found in isolation and thus these concomitant exposures need to be considered when conducting environmental interventions. There have been numerous studies looking at both primary and tertiary prevention strategies and the impact on allergic sensitization and asthma with varied results. While the outcomes of these studies have been mixed, what has emerged is the need for tertiary interventions to be targeted to the individual and to reduce all relevant exposures to which an asthmatic child is exposed and sensitized. In addition, effective intervention strategies must also consider other social determinants of asthma morbidity impacting low socioeconomic, urban communities.

摘要

生活在低收入城市社区的儿童罹患哮喘、因哮喘发作而到急诊室就诊以及因哮喘住院的风险比生活在上层和中层收入社区的儿童高得多。对于许多生活在城市社区的哮喘儿童,尤其是那些发病率较高的儿童,过敏途径在疾病的病因中起着重要作用。过敏性疾病的发展阶段可分为过敏致敏的发生、过敏性疾病的发展和随后的加重,考虑这些阶段的干预措施的相关性是有用的。室内过敏原和环境暴露是过敏性疾病的主要原因,尤其是在社会经济地位较低、城市、少数民族社区。这些暴露包括过敏原、环境烟草烟雾、燃烧产物和霉菌,所有这些都可以在哮喘进展和发病率中发挥重要作用。这些暴露通常不是孤立存在的,因此在进行环境干预时需要考虑这些同时存在的暴露。已经有许多研究关注初级和三级预防策略以及它们对过敏致敏和哮喘的影响,但结果各不相同。尽管这些研究的结果参差不齐,但需要针对个体进行三级干预,以减少哮喘儿童接触和致敏的所有相关暴露。此外,有效的干预策略还必须考虑影响低收入、城市社区的哮喘发病率的其他社会决定因素。

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