Uniformed Services University of the Heath Sciences, Bethesda, Md; Allergy, Immunology, and Immunizations Service, Walter Reed National Military Medical Center, Bethesda, Md.
Division of Pediatric Allergy and Immunology, Johns Hopkins School of Medicine, Baltimore, Md.
J Allergy Clin Immunol Pract. 2018 Jan-Feb;6(1):9-19. doi: 10.1016/j.jaip.2017.10.009.
Over the last 2 to 3 decades, significant advances have been made in understanding the role that indoor allergen exposures play with regard to respiratory health. Multiple studies have confirmed that sensitization and exposure to indoor allergens can be a risk factor for asthma morbidity. Environmental interventions targeting key indoor allergens have been evaluated with the aims of examining their causal effects on asthma-related outcomes and identifying clinically efficacious interventions to incorporate into treatment recommendations. Historically, it appeared that the most successful intervention, as performed in the Inner-City Asthma Study, was individually tailored, targeting multiple allergens in a predominantly low-income, minority, and urban pediatric population. Recent studies suggest that single-allergen interventions may be efficacious when targeting the most clinically relevant allergen for a population. In this article, we review recent literature on home environmental interventions and their effects on specific indoor allergen levels and asthma-related outcomes.
在过去的 2 到 3 十年中,人们对室内过敏原暴露在呼吸健康方面所起的作用有了更深入的了解。多项研究证实,对室内过敏原的致敏和暴露可能是哮喘发病率的一个危险因素。针对关键室内过敏原的环境干预措施已经进行了评估,目的是研究它们对与哮喘相关的结果的因果影响,并确定临床上有效的干预措施纳入治疗建议。从历史上看,最成功的干预措施似乎是在城市内哮喘研究中实施的,该措施针对的是主要为低收入、少数族裔和城市儿科人群的多种过敏原进行个体化治疗。最近的研究表明,针对特定人群最具临床相关性的过敏原进行单一过敏原干预可能是有效的。在本文中,我们回顾了最近关于家庭环境干预及其对特定室内过敏原水平和与哮喘相关结果的影响的文献。