Atiq Muslim, Dosch Kay, Miller Ashley, Sudhagoni Ramu G
Sanford Health, Sioux Falls, SD, USA.
Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
J Gastrointest Cancer. 2020 Mar;51(1):144-151. doi: 10.1007/s12029-019-00214-z.
Pancreatic cancer is the fourth leading cause of cancer-related mortality in the United States. Descriptive epidemiology of pancreatic cancer in South Dakota has not been studied before.
All cases of pancreatic cancer reported to the SD Cancer Registry between January 2005 and December 2014 were included in the study. Variables collected included demographics, geographical location including county of residence and zip codes, date of diagnosis, date of last contact or follow-up, size and location of the tumor, grade of the tumor, diagnostic modality as well as therapeutic interventions. Log rank test was used to compare survival curves. Kaplan-Meier product limit estimates were provided. Data was analyzed using SAS 9.1.4 software.
One thousand sixty-four cases of pancreatic cancer were reported. Median age was 73 years. Cumulative age-adjusted incidence rate for pancreatic cancer for 2005-2014 was 11.1. Cumulative age-adjusted mortality rate for pancreatic cancer for 2005-2014 was 10.2. Almost half of these patients had distant metastasis at the time of presentation (n = 536; 50.4%). Overall, median survival was 5 months. Median survival for patients under the age of 60 years was 9.5 months as opposed to median survival for patients 60 years or older which was 3.9 months. Median survival of patients with well-differentiated, moderately differentiated, and poorly differentiated tumors, was 20.8 months, 8.2 months and 6.3 months respectively (p value = 0.0017).
Incidence of pancreatic cancer in South Dakota is similar to the national trends in the United States. Age at presentation, location of tumor in pancreas, and biological behavior of tumor were all predictors of survival in patients with pancreatic cancer.
胰腺癌是美国癌症相关死亡的第四大主要原因。此前尚未对南达科他州胰腺癌的描述性流行病学进行过研究。
本研究纳入了2005年1月至2014年12月期间向南达科他州癌症登记处报告的所有胰腺癌病例。收集的变量包括人口统计学信息、地理位置（包括居住县和邮政编码）、诊断日期、最后一次联系或随访日期、肿瘤大小和位置、肿瘤分级、诊断方式以及治疗干预措施。采用对数秩检验比较生存曲线。提供了Kaplan-Meier乘积限估计值。使用SAS 9.1.4软件进行数据分析。
共报告了1064例胰腺癌病例。中位年龄为73岁。2005 - 2014年胰腺癌的累积年龄调整发病率为11.1。2005 - 2014年胰腺癌的累积年龄调整死亡率为10.2。这些患者中几乎一半在就诊时已有远处转移（n = 536；50.4%）。总体而言，中位生存期为5个月。60岁以下患者的中位生存期为9.5个月，而60岁及以上患者的中位生存期为3.9个月。高分化、中分化和低分化肿瘤患者的中位生存期分别为20.8个月、8.2个月和6.3个月（p值 = 0.0017）。
南达科他州胰腺癌的发病率与美国的全国趋势相似。就诊年龄、胰腺肿瘤位置以及肿瘤的生物学行为都是胰腺癌患者生存的预测因素。
