Morishita Tetsuji, Uzui Hiroyasu, Nakano Akira, Fukuoka Yoshitomo, Ikeda Hiroyuki, Amaya Naoki, Kaseno Kenichi, Ishida Kentaro, Lee Jong-Dae, Tada Hiroshi
Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka, Shimoaizuki, Eiheiji-cho, Fukui, 910-1193, Japan.
Heart Vessels. 2018 Nov;33(11):1301-1310. doi: 10.1007/s00380-018-1191-8. Epub 2018 May 22.
The aim of this study was to evaluate the relationships among the traditional risk factors, lipid profile, and pentraxin-3 in stable angina (SAP). Plasma pentraxin-3 and serum LDL, HDL, and high-sensitivity CRP levels were measured in 163 SAP and 28 non-coronary artery disease (CAD) patients. Their relationships with five risk factors, hypertension (HT), dyslipidemia (DL), diabetes mellitus (DM), obesity (body mass index: BMI > 25 kg/m), and high age (> 75 years), were evaluated. No significant difference was observed in the pentraxin-3 level between patients in SAP and in non-CAD [2.1 (1.4-3.5) ng/ml versus off 2.6 (1.6-3.8) ng/ml, P = 0.56). In SAP patients, pentraxin-3 levels decreased with more risk factors, according to the number of 3 traditional risk factors (HT, DL, and DM) and the number of 5 expanded risk factors (HT, DL, DM, obesity, and high age) (P for trend = 0.01 and 0.05, respectively). Pentraxin-3 showed a positive association with HDL (rs = 0.229; P = 0.050) and an inverse association with LDL (rs = - 0.224; P = 0.045). On multiple logistic regression, the number of 3 traditional risk factors was a significant predictor of pentraxin-3 levels (odds ratio = 0.444; 95% confidence interval 0.205-0.963, P = 0.040) in SAP patients. In SAP patients, the cardiovascular risk factor burden remained a negative impact on pentraxin-3 levels after multivariate analysis, suggesting that they have distinct roles in atherosclerosis.Trial registration: UMIN000023837.
本研究旨在评估稳定型心绞痛（SAP）患者中传统危险因素、血脂谱与五聚体-3之间的关系。对163例SAP患者和28例非冠状动脉疾病（CAD）患者测定了血浆五聚体-3以及血清低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和高敏C反应蛋白（hs-CRP）水平。评估了它们与五个危险因素的关系，这五个危险因素分别为高血压（HT）、血脂异常（DL）、糖尿病（DM）、肥胖（体重指数：BMI＞25kg/m²）和高龄（＞75岁）。SAP患者与非CAD患者的五聚体-3水平无显著差异[2.1（1.4 - 3.5）ng/ml对2.6（1.6 - 3.8）ng/ml，P = 0.56]。在SAP患者中，根据3个传统危险因素（HT、DL和DM）的数量以及5个扩展危险因素（HT、DL、DM、肥胖和高龄）的数量，五聚体-3水平随危险因素数量增加而降低（趋势P值分别为0.01和0.05）。五聚体-3与HDL呈正相关（rs = 0.229；P = 0.050），与LDL呈负相关（rs = -0.224；P = 0.045）。多因素logistic回归分析显示，3个传统危险因素的数量是SAP患者五聚体-3水平的显著预测因素（比值比 = 0.444；95%置信区间0.205 - 0.963，P = 0.040）。在SAP患者中，多因素分析后心血管危险因素负担对五聚体-3水平仍有负面影响，提示它们在动脉粥样硬化中具有不同作用。试验注册号：UMIN000023837。
