School of Basic Medical Science, Henan University, Kaifeng, Henan, China.
Physiol Res. 2019 Jun 30;68(3):335-345. doi: 10.33549/physiolres.933996. Epub 2019 Mar 22.
Autophagy can regulate cell growth, proliferation, and stability of cell environment. Its dysfunction can be involved in a variety of diseases. Hydrogen sulfide (H(2)S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicate that H(2)S plays an important protective role in many diseases through influencing autophagy, but its mechanism is not fully understood. This article reviewed the progress about the effect of H(2)S on autophagy in diseases in recent years in order to provide theoretical basis for the further research on the interaction of H(2)S and autophagy and the mechanisms involved.
自噬可以调节细胞生长、增殖和细胞环境的稳定性。其功能障碍与多种疾病有关。硫化氢 (H₂S) 是一种重要的信号分子，可调节许多生理和病理过程。最近的研究表明，H₂S 通过影响自噬在许多疾病中发挥重要的保护作用，但它的机制尚不完全清楚。本文综述了近年来关于 H₂S 对疾病中自噬作用的研究进展，以期为进一步研究 H₂S 与自噬的相互作用及其涉及的机制提供理论依据。
