Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, China.
Int J Mol Sci. 2021 Jun 23;22(13):6715. doi: 10.3390/ijms22136715.
Autophagy is a vital cell mechanism which plays an important role in many physiological processes including clearing long-lived, accumulated and misfolded proteins, removing damaged organelles and regulating growth and aging. Autophagy also participates in a variety of biological functions, such as development, cell differentiation, resistance to pathogens and nutritional hunger. Recently, autophagy has been reported to be involved in diabetes, but the mechanism is not fully understood. Hydrogen sulfide (HS) is a colorless, water-soluble, flammable gas with the typical odor of rotten eggs, which has been known as a highly toxic gas for many years. However, it has been reported recently that HS, together with nitric oxide and carbon monoxide, is an important gas signal transduction molecule. HS has been reported to play a protective role in many diabetes-related diseases, but the mechanism is not fully clear. Recent studies indicate that HS plays an important role by regulating autophagy in many diseases including cancer, tissue fibrosis diseases and glycometabolic diseases; however, the related mechanism has not been fully studied. In this review, we summarize recent research on the role of HS in regulating autophagy in diabetic-related diseases to provide references for future related research.
自噬是一种重要的细胞机制，在许多生理过程中发挥重要作用，包括清除寿命长、积累和错误折叠的蛋白质、清除受损的细胞器以及调节生长和衰老。自噬还参与多种生物学功能，如发育、细胞分化、抵抗病原体和营养饥饿。最近，自噬被报道参与糖尿病，但机制尚不完全清楚。硫化氢（HS）是一种无色、水溶性、易燃气体，具有典型的臭鸡蛋气味，多年来一直被认为是一种剧毒气体。然而，最近有报道称，HS 与一氧化氮和一氧化碳一起，是一种重要的气体信号转导分子。HS 已被报道在许多与糖尿病相关的疾病中发挥保护作用，但机制尚不完全清楚。最近的研究表明，HS 通过调节自噬在许多疾病中发挥重要作用，包括癌症、组织纤维化疾病和糖代谢疾病；然而，相关机制尚未完全研究清楚。在这篇综述中，我们总结了 HS 调节糖尿病相关疾病中自噬的最新研究，为未来的相关研究提供参考。
