Elgebaly Mostafa M, Arreguin Jennifer, Storke Niko
Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, Florida.
Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, Florida.
J Stroke Cerebrovasc Dis. 2019 Jun;28(6):1413-1420. doi: 10.1016/j.jstrokecerebrovasdis.2019.02.005. Epub 2019 Mar 20.
Due to multiple failures to translate basic research, the need for novel therapeutic targets and strategies is still urgent to save a larger number of the stroke patients' population and to reduce the toxicity of the current stroke therapy.
We summarize the most recent, within past 5 years, basic and clinical diabetic stroke research findings.
We aim to examine the most current understanding of stroke and neurovascular unit integrity, especially in presence of hyperglycemia and/or diabetes mellitus. From there, we are comparing the meaningful findings that aim at treating diabetic stroke to see where they differ, where they succeed, and where they open questions for new therapeutic strategies.
The need for more clinically effective neuroprotective strategies is still mismatched with the bench side findings.
由于基础研究多次未能成功转化，对于新型治疗靶点和策略的需求仍然迫切，以挽救更多中风患者，并降低当前中风治疗的毒性。
我们总结了过去5年内最新的基础和临床糖尿病性中风研究结果。
我们旨在审视目前对中风和神经血管单元完整性的理解，尤其是在存在高血糖和/或糖尿病的情况下。据此，我们比较旨在治疗糖尿病性中风的有意义的研究结果，以了解它们的不同之处、成功之处以及为新治疗策略带来问题的地方。
临床上更有效的神经保护策略的需求与实验室研究结果仍不匹配。
