Section Medical Psychology and Psychotherapy, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
EuroQol Research Foundation, Rotterdam, The Netherlands.
BMJ Open. 2019 Mar 23;9(3):e025684. doi: 10.1136/bmjopen-2018-025684.
Living donor kidney transplantation (LDKT) is the optimal treatment for most patients with end-stage renal disease (ESRD). However, there are numerous patients who cannot find a living kidney donor. Randomised controlled trials have shown that home-based education for patients with ESRD and their family/friends leads to four times more LDKTs. This educational intervention is currently being implemented in eight hospitals in the Netherlands. Supervision and quality assessment are being employed to maintain the quality of the intervention. In this study, we aim to: (1) conduct a cost-effectiveness analysis of the educational programme and its quality assurance system; (2) investigate the relationship between the quality of the implementation of the intervention and the outcomes knowledge, communication and LDKT activities; and (3) investigate policy implications.
Patients with ESRD who do not have a living kidney donor are eligible to receive the home-based educational intervention. This is carried out by allied health transplantation professionals and psychologists across eight hospitals in the Netherlands. The cost-effectiveness analysis will be conducted with a Markov model. Cost data will be obtained from the literature. We will obtain the quality of life data from the patients who participate in the educational programme. Questionnaires on knowledge and communication will be used to measure the outcomes of the programme. Data on LDKT activities will be obtained from medical records up to 24 months after the education. A protocol adherence measure will be assessed by a third party by means of a telephone interview with the patients and the invitees.
Ethical approval was obtained through all participating hospitals. Results will be disseminated through peer-reviewed publications and scientific presentations. Results of the cost-effectiveness of the educational programme will also be disseminated to the Dutch National Health Care Institute.
NL6529.
活体供肾移植（LDKT）是大多数终末期肾病（ESRD）患者的最佳治疗方法。然而，有许多患者找不到活体肾脏供体。随机对照试验表明，对 ESRD 患者及其家属/朋友进行家庭为基础的教育可使 LDKT 增加四倍。该教育干预目前正在荷兰的八家医院实施。正在采用监督和质量评估来维持干预措施的质量。在这项研究中，我们旨在：（1）对教育计划及其质量保证系统进行成本效益分析；（2）研究干预措施实施质量与知识、沟通和 LDKT 活动结果之间的关系；（3）研究政策含义。
没有活体肾脏供体的 ESRD 患者有资格接受家庭为基础的教育干预。这是由荷兰八家医院的联合健康移植专业人员和心理学家进行的。将使用马尔可夫模型进行成本效益分析。成本数据将从文献中获得。我们将从参加教育计划的患者中获得生活质量数据。知识和沟通问卷将用于衡量计划的结果。LDKT 活动的数据将从教育后 24 个月的病历中获得。通过与患者和受邀者进行电话访谈，由第三方评估协议遵守度。
所有参与的医院均获得了伦理批准。结果将通过同行评审的出版物和科学演讲进行传播。教育计划的成本效益结果也将传播给荷兰国家卫生保健研究所。
NL6529。
