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术中富血小板血浆能否改善肩袖肌腱孤立性撕裂关节镜修复术后的临床和结构预后?

Does Intraoperative Platelet-rich Plasma Improve Clinical and Structural Outcomes after Arthroscopic Repair of Isolated Tears of the Supraspinatus Tendon?

作者信息

Martinelli Daniela, Fornara Paolo, Stecco Alessandro, Grassi Federico Alberto

机构信息

Department of Health Sciences, University of East Piedmont, Novara, Italy.

Hospital "Maggiore della Carità", Novara, Italy.

出版信息

Indian J Orthop. 2019 Jan-Feb;53(1):77-81. doi: 10.4103/ortho.IJOrtho_35_17.

DOI:10.4103/ortho.IJOrtho_35_17
PMID:30905985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6394193/
Abstract

BACKGROUND

Arthroscopic cuff repair is a highly successful technique, but postoperative rehabilitation is complex and the rate of tear recurrence is not negligible. Biological augmentations have been proposed to overcome these drawbacks. The platelet-rich plasma (PRP) is a platelet-rich blood fraction that is applied on the repair site to enhance tendon healing. This study evaluates the effectiveness of PRP application in arthroscopic cuff repair.

MATERIALS AND METHODS

A prospective nonrandomized study was carried out on 22 patients undergoing arthroscopic rotator cuff repair. Only patients with isolated and repairable supraspinatus tears were included and divided into two groups: 11 patients (Group A) received intraoperative PRP and 11 patients (Group B) did not. All patients had the same rehabilitation and followup protocol. Clinical-functional parameters (visual analog score, active range of motion, University of California at Los Angeles - UCLA, Constant) were recorded at predefined intervals, and magnetic resonance imaging (MRI) was performed 1 year postoperative.

RESULTS

Only one patient of Group B did not complete the study protocol. No intraoperative or postoperative complications were observed. No differences were found in the clinical-functional parameters during the entire study. At 1 year, MRI showed 1 retear in Group A and 2 retears in Group B, but the difference was not significant.

CONCLUSIONS

The role of PRP as an adjuvant for surgical repair of rotator cuff tears is controversial. In this study, we could not demonstrate significant advantages of PRP for arthroscopic repair of isolated supraspinatus tears. The potential improvement in the structural outcome should be evaluated in the long term to justify the additional costs related to PRP application.

摘要

背景

关节镜下肩袖修复是一种非常成功的技术,但术后康复复杂,撕裂复发率不可忽视。已提出使用生物增强技术来克服这些缺点。富血小板血浆(PRP)是一种富含血小板的血液成分,应用于修复部位以促进肌腱愈合。本研究评估了PRP在关节镜下肩袖修复中的有效性。

材料与方法

对22例接受关节镜下肩袖修复的患者进行了一项前瞻性非随机研究。仅纳入孤立且可修复的冈上肌撕裂患者,并分为两组:11例患者(A组)术中接受PRP,11例患者(B组)未接受。所有患者均采用相同的康复和随访方案。在预定时间间隔记录临床功能参数(视觉模拟评分、主动活动范围、加州大学洛杉矶分校 - UCLA、Constant评分),并在术后1年进行磁共振成像(MRI)检查。

结果

B组仅1例患者未完成研究方案。未观察到术中或术后并发症。在整个研究过程中,临床功能参数未发现差异。1年后,MRI显示A组有1例再次撕裂,B组有2例再次撕裂,但差异无统计学意义。

结论

PRP作为肩袖撕裂手术修复辅助手段的作用存在争议。在本研究中,我们未能证明PRP在关节镜下修复孤立冈上肌撕裂方面具有显著优势。结构结局的潜在改善应进行长期评估,以证明与应用PRP相关的额外费用合理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc6/6394193/4ac18b6ef694/IJOrtho-53-77-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc6/6394193/67d504f6575b/IJOrtho-53-77-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc6/6394193/1d89e1ff0e34/IJOrtho-53-77-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc6/6394193/4ac18b6ef694/IJOrtho-53-77-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc6/6394193/67d504f6575b/IJOrtho-53-77-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc6/6394193/1d89e1ff0e34/IJOrtho-53-77-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc6/6394193/4ac18b6ef694/IJOrtho-53-77-g003.jpg

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