Lee Katarzyna N, Lee Johnny W, Ngai Ming-Yu
Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Institute of Chemical Biology and Drug Discovery, Stony Brook University Stony Brook, NY 11794-3400, USA.
Tetrahedron. 2018 Dec 13;74(50):7127-7135. doi: 10.1016/j.tet.2018.09.020. Epub 2018 Sep 13.
Trifluoromethoxy (OCF) group exhibits unique properties, which render it a highly desirable structural motif in life and materials sciences. The numbers of newly synthesized trifluoromethyl ethers are booming as new synthetic methods are constantly being developed to access these valuable compounds. This Review summarizes recent catalytic approaches towards preparation of trifluoromethyl ethers. Alkene, allylic, benzylic, and aryl trifluoromethoxylation reactions are discussed herein.
三氟甲氧基（OCF）基团具有独特的性质，这使其成为生命科学和材料科学中非常理想的结构单元。随着不断开发新的合成方法来获取这些有价值的化合物，新合成的三氟甲基醚的数量正在迅速增加。本综述总结了近期制备三氟甲基醚的催化方法。本文讨论了烯烃、烯丙基、苄基和芳基的三氟甲氧基化反应。
