与皮肤屏障形成和功能相关的四种异构体亚油酸三醇的立体控制合成。
Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function.
作者信息
Davis Robert W, Allweil Alexander, Tian Jianhua, Brash Alan R, Sulikowski Gary A
机构信息
Department of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA.
Department of Pharmacology, Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.
出版信息
Tetrahedron Lett. 2018 Dec 26;59(52):4571-4573. doi: 10.1016/j.tetlet.2018.11.033. Epub 2018 Nov 10.
Abstract
Linoleate triol esters are intermediates along the pathway of formation of the mammalian skin permeability barrier. In connection with the study of their involvement in barrier formation we required access to isomerically pure and defined samples of four linoleate triol esters. A common synthetic strategy was developed starting from isomeric alkynols derived from d-tartaric acid and 2-deoxy-d-ribose.
摘要
亚油酸三醇酯是哺乳动物皮肤渗透屏障形成途径中的中间体。在研究它们参与屏障形成的过程中，我们需要获得四种亚油酸三醇酯的异构体纯的和特定的样品。从由d - 酒石酸和2 - 脱氧 - d - 核糖衍生的异构体炔醇开始，开发了一种通用的合成策略。
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