Introduction  Surgical treatment of pediatric kidney stones has dramatically changed in recent years due to the miniaturization of surgical instruments and the availability of intracorporeal lithotriptors. Retrograde intrarenal surgery (RIRS) technique is now considered an effective and minimally invasive procedure in renal stones. However, in the pediatric age group, the number of studies on this subject is very limited. The aim of this study was to evaluate the efficacy and safety of the RIRS in the treatment of kidney stones in children. Material and methods  The data of 25 pediatric stone patients who underwent RIRS with the diagnosis of kidney stones were analyzed retrospectively. Demographic characteristics, operative data, and success rates of the patients were recorded. Results  Fourteen (56%) of the cases were male and 11 (46%) were female. The mean age was 10.43 ± 4.26 (3-15) in boys and 10.18 ± 4.92 (4-16) in girls. Eleven stones (46%) were in the left kidney and 14 (56%) in the right kidney. The mean stone size was 10.08 ± 4.33 mm (4-23). Stone localizations were renal pelvis in 15 (60%) cases, upper calyx in four (16%) cases, middle calyx in five (20%) cases, and lower calyx in one (4%) case. The mean operation time was 41.20 ± 6.96 minutes (30-60), the mean duration of scope was 17.40 ± 3.85 seconds (10-30), and the mean hospital stay was 2.32 ± 0.63 days (2-4). Three patients (12%) had undergone percutaneous nephrolithotomy (PCNL), and two (8%) patients underwent shockwave lithotripsy (ESWL) before this surgery. In six (24%) patients, a double J (DJ) catheter was inserted due to stenosis at the lower end of the ureter. Body mass index (BMI) of these patients was below 18. An access sheath was implanted in six (24%) patients in the second operation. In 18 cases, the first operation was performed with a direct flexible renoscope. In all cases, a postoperative DJ catheter was inserted. Postoperative fever was observed in one (4%) patient, and ureteric steinstrasse was observed in one (4%) patient. The stone-free rate was achieved as 17% (68%) after the first operation and 100% after the second RIRS session. Conclusion  RIRS appears to be an effective and reliable method in the pediatric age group. However, there is a need for multicentre studies involving more cases.