Asai Nobuhiro, Kubo Akihito, Suzuki Susumu, Murotani Kenta, Numanami Hiroki, Yoshikawa Kazuhiro, Ueda Ryuzo, Yamaguchi Etsuro
a Division of Respiratory Medicine and Allergology, Department of Internal Medicine , Aichi Medical University School of Medicine , Nagakute , Japan.
b Department of Tumor Immunology , Aichi Medical University School of Medicine , Nagakute , Japan.
Cancer Invest. 2019;37(3):163-173. doi: 10.1080/07357907.2019.1582848. Epub 2019 Mar 25.
To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4 eTregs to total Tregs (≥40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p = .007) and overall survival (OR: 3.76, p = .037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.
为阐明肿瘤浸润效应调节性T细胞（eTregs）在非小细胞肺癌（NSCLC）中的预后影响，通过免疫组化检测CCR4和Foxp3对108例连续手术切除的NSCLC肿瘤中的eTregs进行评估。多变量分析显示，在肺鳞状细胞癌（SqCC）中，CCR4 eTregs与总Tregs的高比例（≥40%）是无复发生存（优势比[OR]：6.54，95%置信区间：1.67 - 25.7，p = 0.007）和总生存（OR：3.76，p = 0.037）的唯一独立危险因素。这些结果突出了肿瘤浸润Tregs平衡在切除的肺SqCC中的预后重要性。
