Research & Development, Kao Corporation , Tokyo , Japan.
Center of Diabetes, Endocrinology & Metabolism, Toho University Sakura Medical Center , Chiba , Japan.
Int J Food Sci Nutr. 2019 Nov;70(7):901-908. doi: 10.1080/09637486.2019.1585763. Epub 2019 Mar 25.
The effect of chlorogenic acid-enriched green coffee bean extract (cGCE) intake on arterial stiffness was investigated using the cardio-ankle vascular index (CAVI) as a novel surrogate marker for predicting arteriosclerosis. A placebo-controlled double-blind pilot study was conducted with 16 healthy Japanese men. Subjects were divided into two groups and consumed beverages containing either cGCE or placebo daily for 2 weeks. The CAVI, the primary endpoint of the study, was evaluated at the beginning of the study and 2 weeks later. Endothelium-dependent flow-mediated dilation (FMD) and sympathetic nervous activity (SNA), which are thought to be related to the CAVI, were also measured. The CAVI change was significantly greater in the cGCE group than in the placebo group. In addition, FMD increased and SNA decreased in the cGCE group. These findings suggest that 2-week ingestion of cGCE may improve arterial stiffness as assessed by the CAVI.
研究了富含绿原酸的咖啡提取物（cGCE）对动脉僵硬的影响，使用心血管-踝血管指数（CAVI）作为预测动脉硬化的新型替代标志物。对 16 名健康的日本男性进行了一项安慰剂对照、双盲的初步研究。将受试者分为两组，每日饮用含有 cGCE 或安慰剂的饮料，持续 2 周。在研究开始时和 2 周后评估研究的主要终点 CAVI。还测量了被认为与 CAVI 相关的内皮依赖性血流介导的扩张（FMD）和交感神经活性（SNA）。cGCE 组的 CAVI 变化明显大于安慰剂组。此外，cGCE 组的 FMD 增加，SNA 降低。这些发现表明，摄入 cGCE 2 周可能会改善 CAVI 评估的动脉僵硬。
