Department of Nursing, Faculty of Medicine, Brawijaya University, Malang, East java, +62, Indonesia.
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University-Saiful Anwar General Hospital, Malang, East java, +62, Indonesia.
F1000Res. 2020 Dec 15;9:1462. doi: 10.12688/f1000research.26236.1. eCollection 2020.
Vascular endothelial cells have a variety of functions such as the control of blood coagulation, vascular permeability, and tone regulation, as well as quiesce of immune cells. Endothelial dysfunction is a cardiovascular events predictor, which is considered the initial stage in atherosclerosis development. It is characterized by alterations in endothelium functions due to imbalanced vasodilators and vasoconstrictors, procoagulant and anticoagulant mediators, as well as growth inhibitor and promotor substances. Chlorogenic acid (CGA) is the primary polyphenol in coffee and some fruits. It has many health-promoting properties, especially in the cardiovascular system. Many studies investigated the efficacy and mechanism of this compound in vascular health. CGA has several vascular benefits such as anti-atherosclerosis, anti-thrombosis, and anti-hypertensive. This review focuses on the molecular mechanism of CGA in vascular health.
血管内皮细胞具有多种功能，如控制血液凝固、血管通透性和张力调节，以及使免疫细胞静止。内皮功能障碍是心血管事件的预测因子，被认为是动脉粥样硬化发展的初始阶段。其特征是由于血管舒张剂和血管收缩剂、促凝和抗凝介质以及生长抑制剂和促进剂物质的失衡，导致内皮功能改变。绿原酸（CGA）是咖啡和一些水果中的主要多酚。它具有许多促进健康的特性，特别是在心血管系统中。许多研究调查了这种化合物在血管健康中的功效和机制。CGA 具有多种血管益处，如抗动脉粥样硬化、抗血栓形成和抗高血压。本综述重点介绍 CGA 在血管健康中的分子机制。
