髓鞘少突胶质细胞糖蛋白抗体相关脑脊髓炎/脑炎
MOG antibody-associated encephalomyelitis/encephalitis.
作者信息
Salama Sara, Khan Majid, Pardo Santiago, Izbudak Izlem, Levy Michael
机构信息
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA/Department of Neurology, University of Alexandria, Alexandria, Egypt.
Department of Neuroradiology, Johns Hopkins University, Baltimore, MD, USA.
出版信息
Mult Scler. 2019 Oct;25(11):1427-1433. doi: 10.1177/1352458519837705. Epub 2019 Mar 25.
Abstract
Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM). In this review, we discuss MOG-positive cases presenting with encephalitis, encephalopathy, or ADEM-like presentation based on recently published series.
摘要
髓鞘少突胶质细胞糖蛋白（MOG）抗体病是一种罕见的自身免疫性疾病，针对MOG的抗体主要累及视神经和脊髓，导致视力丧失和瘫痪。当MOG抗体病累及大脑时，其表型类似于急性播散性脑脊髓炎（ADEM）。在本综述中，我们根据最近发表的系列病例讨论表现为脑炎、脑病或ADEM样表现的MOG阳性病例。
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