Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
School of Medicine, Zhejiang University City College, Hangzhou 310058, China.
Curr Pharm Des. 2019;25(2):155-165. doi: 10.2174/1381612825666190321104424.
Rheumatoid Arthritis (RA) is a systemic autoimmune disease accompanied by chronic inflammation. Due to the long-term infiltration in inflammatory sites, joints get steadily deteriorated, eventually resulting in functional incapacitation and disability. Despite the considerable effect, RA sufferers treated with current drug therapeutic efficacy are exposed to severe side effects. Application of Drug Delivery Systems (DDS) has improved these situations while the problem of limited drug exposure remains untackled. Stimuli-responsive DDS that are responsive to a variety of endogenous and exogenous stimuli, such as pH, redox status, and temperature, have emerged as a promising therapeutic strategy to optimize the drug release. Herein, we discussed the therapeutic regimes and serious side effects of current RA therapy, as well as focused on some of the potential stimuliresponsive DDS utilized in RA therapy. Besides, the prospective room in designing DDS for RA treatment has also been discussed.
类风湿关节炎（RA）是一种系统性自身免疫性疾病，伴有慢性炎症。由于炎症部位的长期浸润，关节逐渐恶化，最终导致功能丧失和残疾。尽管目前的药物治疗效果显著，但接受治疗的 RA 患者仍面临严重的副作用。药物传递系统（DDS）的应用改善了这些情况，但药物暴露有限的问题仍未得到解决。对各种内源性和外源性刺激（如 pH 值、氧化还原状态和温度）敏感的响应型 DDS 已成为优化药物释放的一种有前途的治疗策略。本文讨论了目前 RA 治疗的治疗方案和严重的副作用，并重点介绍了一些用于 RA 治疗的潜在刺激响应型 DDS。此外，还讨论了设计用于 RA 治疗的 DDS 的未来发展空间。
