Ktsoeva T V
Ter Arkh. 1986;58(5):127-31.
The paper is concerned with the results of therapy of CHD patients with circulatory insufficiency using cardiac glycosides combined with a nitrate of prolonged action (sustak) and an arterial dilator apressin. Since the patients were advanced in years, sustak was given at average doses of 6.4 mg every 8 h and apressin at a daily dose of 75 mg. Additional treatment with vasodilators resulted in positive hemodynamic shifts in the patients with stage IIA and IIB circulatory insufficiency. The highest hemodynamic effect in therapy of marked circulatory insufficiency was observed in the patients with a low initial cardiac output and a high peripheral vascular resistance after multimodality therapy (cardiac glycosides, sustak and apressin). Changes in hemodynamics should be taken into account during therapy with vasodilators and control over their efficacy should be exercised.
本文关注的是使用强心苷联合长效硝酸盐（长效硝酸甘油）和动脉扩张剂阿普明治疗伴有循环功能不全的冠心病患者的结果。由于患者年事已高，长效硝酸甘油的平均给药剂量为每8小时6.4毫克，阿普明的日剂量为75毫克。对患有IIA期和IIB期循环功能不全的患者，使用血管扩张剂进行额外治疗可导致积极的血液动力学改变。在多模式治疗（强心苷、长效硝酸甘油和阿普明）后，初始心输出量低且外周血管阻力高的患者在治疗明显循环功能不全时观察到最高的血液动力学效应。在使用血管扩张剂治疗期间应考虑血液动力学变化，并应对其疗效进行监测。
