Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, Białystok, Poland.
Department of Pediatrics and Nephrology, Medical University of Bialystok, Białystok, Poland.
Curr Drug Metab. 2019;20(5):332-349. doi: 10.2174/1389200220666190321142417.
Acute Kidney Injury (AKI) is a sudden decrease in kidney function. In the early period, the highest percentage of AKI occurs among newborns hospitalized in the neonatal intensive care units, especially premature neonates. The prognosis of AKI depends on the type and severity of the cause of an injury, the accuracy and the time of diagnosis and treatment. The concentration of serum creatinine is still the main diagnostic test, although it changes in the course of AKI later than glomerular filtration rate GFR. In addition, the reliability of the determination of creatinine level is limited because it depends on many factors. New studies have presented other, more useful laboratory markers of renal function that can be measured in serum and/or in urine.
The aim of the work was to present the latest data about tubular and glomerular biomarkers of acute kidney injury in newborns.
We undertook a structured search of bibliographic databases for peer-reviewed research literature by using focused review topics. According to the conceptual framework, the main idea of research literature has been summarized and presented in this study.
The concentrations of some novel biomarkers are higher in serum and/or urine of term and preterm newborns with AKI, especially in the course of perinatal asphyxia.
In this systematic review of the literature, we have highlighted the usefulness of biomarkers in predicting tubular and/or glomerular injury in newborns. However, novel biomarkers need to prove their clinical applicability, accuracy, and cost-effectiveness prior to their implementation in clinical practice.
急性肾损伤 (AKI) 是肾功能的突然下降。在早期，住院于新生儿重症监护病房的新生儿中 AKI 的发生率最高，尤其是早产儿。AKI 的预后取决于损伤的类型和严重程度、诊断和治疗的准确性和及时性。血清肌酐浓度仍然是主要的诊断试验，尽管它在 AKI 过程中的变化比肾小球滤过率 (GFR) 晚。此外，由于肌酐水平的测定受许多因素的限制，其可靠性有限。新的研究提出了其他更有用的肾功能实验室标志物，可以在血清和/或尿液中测量。
本研究旨在介绍新生儿急性肾损伤的最新肾小管和肾小球生物标志物数据。
我们通过使用重点综述主题对同行评审的研究文献进行了结构化的文献数据库搜索。根据概念框架，本研究总结和呈现了研究文献的主要思想。
一些新型生物标志物在 AKI 足月和早产儿的血清和/或尿液中的浓度更高，尤其是在围产期窒息过程中。
在对文献的系统综述中，我们强调了生物标志物在预测新生儿肾小管和/或肾小球损伤方面的作用。然而，新型生物标志物需要在临床实践中证明其临床适用性、准确性和成本效益。
