对一些用作金属中毒螯合药物的聚氨基羧酸的半数致死剂量的评估。
Evaluation of LD50 of some polyaminocarboxylic acids used as chelating drugs in metal intoxication.
作者信息
Srivastava R C, Dwivedi P P, Behari J R, Athar M
出版信息
Toxicol Lett. 1986 Jul-Aug;32(1-2):37-40. doi: 10.1016/0378-4274(86)90046-9.
The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA. A possible correlation between the toxicity and molecular structure of the compounds is discussed.
通过腹腔注射后大鼠的死亡率评估了以下金属结合螯合药物（乙二胺四乙酸（EDTA）、二乙烯三胺五乙酸（DTPA）、羟乙二胺三乙酸（HEDTA）、环己二胺四乙酸（CDTA）和三亚乙基四胺六乙酸（TTHA））的半数致死剂量（LD50），结果发现顺序如下：CDTA > EDTA > DTPA > TTHA > HEDTA。讨论了这些化合物的毒性与分子结构之间可能存在的相关性。
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