College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, P.R. China.
Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, State Oceanic Administration, Daxue Road, Xiamen, 361005, Fujian, P.R. China.
Food Funct. 2019 Apr 1;10(4):2030-2039. doi: 10.1039/c9fo00077a. Epub 2019 Mar 25.
Resveratrol exists widely in plant species and has a variety of anti-oxidant, anti-inflammatory, and immunomodulatory properties. However, there have been few reports regarding its anti-food allergic activity. In this study, we demonstrated that resveratrol (isolated from Abies georgei) could decrease the release of β-hexosaminidase and histamine in rat basophilic leukemia-2H3 cells. Resveratrol was not only found to suppress the development of diarrhea, up-regulate the rectal temperature of ovalbumin-allergic mice, and decrease the serum level of specific immunoglobulin E, mouse mast cell protease-1 and histamine, but also found to decrease the population of dendritic cells, B cells and mast cells of ovalbumin -allergic mice in the spleen or mesenteric lymph node. Furthermore, resveratrol inhibited the release of β-hexosaminidase and histamine in bone marrow-derived cells and alleviated mast cell-mediated passive cutaneous anaphylaxis reactions. These findings indicated that resveratrol isolated from Abies georgei might have the potential to alleviate food hypersensitivity or allergic disease.
白藜芦醇广泛存在于植物物种中，具有多种抗氧化、抗炎和免疫调节特性。然而，关于其抗食物过敏活性的报道较少。在这项研究中，我们证明了白藜芦醇（从乔治亚冷杉中分离得到）可以减少大鼠嗜碱性白血病-2H3 细胞中β-己糖胺酶和组胺的释放。白藜芦醇不仅可以抑制腹泻的发展，上调卵清蛋白过敏小鼠的直肠温度，降低血清特异性免疫球蛋白 E、鼠肥大细胞蛋白酶-1 和组胺水平，还可以减少卵清蛋白过敏小鼠脾脏或肠系膜淋巴结中树突状细胞、B 细胞和肥大细胞的数量。此外，白藜芦醇抑制骨髓来源细胞中β-己糖胺酶和组胺的释放，并缓解肥大细胞介导的被动皮肤过敏反应。这些发现表明，从乔治亚冷杉中分离得到的白藜芦醇可能具有缓解食物过敏或过敏性疾病的潜力。
