Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Adv Mater. 2019 May;31(21):e1808325. doi: 10.1002/adma.201808325. Epub 2019 Mar 25.
Over the past 3 years, glucose oxidase (GOx) has aroused great research interest in the context of cancer treatment due to its inherent biocompatibility and biodegradability, and its unique catalytic properties against β-d-glucose. GOx can effectively catalyze the oxidation of glucose into gluconic acid and hydrogen peroxide. This process depletes oxygen levels, resulting in elevated acidity, hypoxia, and oxidative stress in the tumor microenvironment. All of these changes can be readily harnessed to develop a multimodal synergistic cancer therapy by combining GOx with other therapeutic approaches. Herein, the representative studies of GOx-instructed multimodal synergistic cancer therapy are introduced, and their synergistic mechanisms are discussed systematically. The current challenges and future prospects to advance the development of GOx-based nanomedicines in this cutting-edge research area are highlighted.
在过去的 3 年中，葡萄糖氧化酶（GOx）由于其固有的生物相容性和生物降解性，以及其针对β-d-葡萄糖的独特催化特性，在癌症治疗领域引起了极大的研究兴趣。GOx 可以有效地催化葡萄糖氧化为葡萄糖酸和过氧化氢。这个过程会消耗氧气，导致肿瘤微环境中的酸度升高、缺氧和氧化应激。所有这些变化都可以通过将 GOx 与其他治疗方法结合起来，开发出一种多模式协同癌症治疗方法。本文介绍了 GOx 指导的多模式协同癌症治疗的代表性研究，并系统地讨论了它们的协同机制。强调了当前在这一前沿研究领域推进基于 GOx 的纳米药物发展所面临的挑战和未来前景。
