Brown Z, Neild G H, Willoughby J J, Somia N V, Cameron S J
Transplantation. 1986 Aug;42(2):150-3. doi: 10.1097/00007890-198608000-00009.
Very high plasma concentrations of factor-VIII-related antigen (RAG) (VIII-RAG) were found in renal allograft recipients during periods of nephrotoxicity induced by cyclosporine. In eight recipients, who were investigated at weekly intervals, levels of factor-VIII-RAG fell toward normal as the dose of cyclosporine was reduced. Plasma levels of C-reactive protein, an acute phase reactant protein, were never raised in these recipients. These findings are further evidence that toxic doses of cyclosporine are associated with vascular injury.
在环孢素诱导肾毒性期间，肾移植受者体内发现了非常高的血浆浓度的因子VIII相关抗原（RAG）（VIII - RAG）。在八名每周接受检查的受者中，随着环孢素剂量的减少，因子VIII - RAG水平降至正常。这些受者的血浆C反应蛋白（一种急性期反应蛋白）水平从未升高。这些发现进一步证明，环孢素的毒性剂量与血管损伤有关。
