Ayesa-Arriola Rosa, Tordesillas-Gutierrez Diana, Setién-Suero Esther, Remón-Gallo Diego, González María Del Carmen García, Albacete Auria, Blanco-Campal Alberto, Rodríguez-Sánchez Jose Manuel, Crespo-Facorro Benedicto
Department of Psychiatry.
Faculty of Sciences.
Neuropsychology. 2019 May;33(4):568-580. doi: 10.1037/neu0000540. Epub 2019 Mar 25.
The present study aimed to comprehensively study the specific neurocognitive constructs underlying verbal memory deficits and their neuroanatomical correlates in first episode psychosis (FEP) patients.
A total of 218 FEP patients and 145 healthy participants were examined with the Rey Auditory Verbal Learning Test (a widely used verbal memory measure that provides a range of performance indexes to evaluate memory) and voxel-based morphometry (a neuroimaging analysis technique that allows investigation of focal differences in brain anatomy).
The analyses showed that the FEP group presented significantly lower scores on acquisition/learning, (1, 566) = 40.7; < .001, and delayed recall, (1, 570) = 74.12; < .001, as well as higher rates of forgetting, (1, 566) = 20.03; < .001. They also exhibited a significant sensitivity to retroactive, (1, 554) = 8.74; = .003, but not to proactive interference. Neuroimaging analyses found significant interactions between bilateral frontal lobe morphometry and proactive interference (ρFWE = 0.023). Rate of forgetting also significantly interacted with right occipital cortex morphometry (ρFWE = 0.033). Patients with higher rates of forgetting, proactive and retroactive interference demonstrated further gray matter reductions in frontal and occipital cortical areas.
These findings emphasize the anterior orbitofrontal cortex as the brain region that contributes to verbal memory deficits in FEP patients, and suggest specific relationships between different neuroanatomical structures and discrete verbal memory processes. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
本研究旨在全面探究首发精神病（FEP）患者言语记忆缺陷背后的特定神经认知结构及其神经解剖学关联。
共有218名FEP患者和145名健康参与者接受了雷伊听觉词语学习测验（一种广泛使用的言语记忆测量方法，可提供一系列表现指标来评估记忆）和基于体素的形态测量法（一种神经影像学分析技术，可用于研究脑解剖结构中的局灶性差异）检查。
分析表明，FEP组在获取/学习方面得分显著更低，（1, 566） = 40.7；P <.001，延迟回忆方面得分也显著更低，（1, 570） = 74.12；P <.001，且遗忘率更高，（1, 566） = 20.03；P <.001。他们对倒摄抑制也表现出显著敏感性，（1, 554） = 8.74；P =.003，但对前摄抑制不敏感。神经影像学分析发现双侧额叶形态测量与前摄抑制之间存在显著交互作用（ρFWE = 0.023）。遗忘率也与右侧枕叶皮质形态测量存在显著交互作用（ρFWE = 0.033）。遗忘率、前摄抑制和倒摄抑制较高的患者在额叶和枕叶皮质区域灰质进一步减少。
这些发现强调了眶额前皮质是导致FEP患者言语记忆缺陷的脑区，并表明不同神经解剖结构与离散言语记忆过程之间存在特定关系。（PsycINFO数据库记录（c）2019美国心理学会，保留所有权利）
