Kennedy Eamonn, Liebel Spencer W, Lindsey Hannah M, Vadlamani Shashank, Lei Pui-Wa, Adamson Maheen M, Alda Martin, Alonso-Lana Silvia, Anderson Tim J, Arango Celso, Asarnow Robert F, Avram Mihai, Ayesa-Arriola Rosa, Babikian Talin, Banaj Nerisa, Bird Laura J, Borgwardt Stefan, Brodtmann Amy, Brosch Katharina, Caeyenberghs Karen, Calhoun Vince D, Chiaravalloti Nancy D, Cifu David X, Crespo-Facorro Benedicto, Dalrymple-Alford John C, Dams-O'Connor Kristen, Dannlowski Udo, Darby David, Davenport Nicholas, DeLuca John, Diaz-Caneja Covadonga M, Disner Seth G, Dobryakova Ekaterina, Ehrlich Stefan, Esopenko Carrie, Ferrarelli Fabio, Frank Lea E, Franz Carol E, Fuentes-Claramonte Paola, Genova Helen, Giza Christopher C, Goltermann Janik, Grotegerd Dominik, Gruber Marius, Gutierrez-Zotes Alfonso, Ha Minji, Haavik Jan, Hinkin Charles, Hoskinson Kristen R, Hubl Daniela, Irimia Andrei, Jansen Andreas, Kaess Michael, Kang Xiaojian, Kenney Kimbra, Keřková Barbora, Khlif Mohamed Salah, Kim Minah, Kindler Jochen, Kircher Tilo, Knížková Karolina, Kolskår Knut K, Krch Denise, Kremen William S, Kuhn Taylor, Kumari Veena, Kwon Junsoo, Langella Roberto, Laskowitz Sarah, Lee Jungha, Lengenfelder Jean, Liou-Johnson Victoria, Lippa Sara M, Løvstad Marianne, Lundervold Astri J, Marotta Cassandra, Marquardt Craig A, Mattos Paulo, Mayeli Ahmad, McDonald Carrie R, Meinert Susanne, Melzer Tracy R, Merchán-Naranjo Jessica, Michel Chantal, Morey Rajendra A, Mwangi Benson, Myall Daniel J, Nenadić Igor, Newsome Mary R, Nunes Abraham, O'Brien Terence, Oertel Viola, Ollinger John, Olsen Alexander, Ortiz García de la Foz Victor, Ozmen Mustafa, Pardoe Heath, Parent Marise, Piras Fabrizio, Piras Federica, Pomarol-Clotet Edith, Repple Jonathan, Richard Geneviève, Rodriguez Jonathan, Rodriguez Mabel, Rootes-Murdy Kelly, Rowland Jared, Ryan Nicholas P, Salvador Raymond, Sanders Anne-Marthe, Schmidt Andre, Soares Jair C, Spalleta Gianfranco, Španiel Filip, Sponheim Scott R, Stasenko Alena, Stein Frederike, Straube Benjamin, Thames April, Thomas-Odenthal Florian, Thomopoulos Sophia I, Tone Erin B, Torres Ivan, Troyanskaya Maya, Turner Jessica A, Ulrichsen Kristine M, Umpierrez Guillermo, Vecchio Daniela, Vilella Elisabet, Vivash Lucy, Walker William C, Werden Emilio, Westlye Lars T, Wild Krista, Wroblewski Adrian, Wu Mon-Ju, Wylie Glenn R, Yatham Lakshmi N, Zunta-Soares Giovana B, Thompson Paul M, Pugh Mary Jo, Tate David F, Hillary Frank G, Wilde Elisabeth A, Dennis Emily L
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Division of Epidemiology, University of Utah, Salt Lake City, UT 84108, USA.
Brain Sci. 2024 Jun 29;14(7):669. doi: 10.3390/brainsci14070669.
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinson's disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals. Random forest models identified age, years of education, and site as important VLM covariates. A Bayesian harmonization approach was used to isolate and remove site effects. Regression estimated the adjusted association of each clinical group with VLM scores. Memory deficits were strongly associated with dementia and schizophrenia ( < 0.001), while neither depression nor ADHD showed consistent associations with VLM scores ( > 0.05). Differences associated with clinical conditions were larger for longer delayed recall duration items. By comparing VLM across clinical conditions, this study provides a foundation for enhanced diagnostic precision and offers new insights into disease management of comorbid disorders.
记忆表现缺陷与多种神经和神经精神疾病有关。虽然许多研究评估了个体疾病对记忆的影响，但本研究通过使用来自55项国际研究的数据，汇总了15883名年龄在15 - 90岁的独特参与者，从更广泛的角度评估了记忆回忆与九种常见神经精神疾病的差异关联。相对于匹配的健康个体，估计了痴呆症、轻度认知障碍、帕金森病、创伤性脑损伤、中风、抑郁症、注意力缺陷多动障碍（ADHD）、精神分裂症和双相情感障碍对即时、短期和长期延迟言语学习和记忆（VLM）分数的影响。随机森林模型确定年龄、受教育年限和研究地点是重要的VLM协变量。采用贝叶斯协调方法来分离和消除研究地点的影响。回归分析估计了每个临床组与VLM分数的校正关联。记忆缺陷与痴呆症和精神分裂症密切相关（<0.001），而抑郁症和ADHD与VLM分数均未显示出一致的关联（>0.05）。对于延迟回忆持续时间较长的项目，与临床疾病相关的差异更大。通过比较不同临床疾病的VLM，本研究为提高诊断准确性提供了基础，并为共病疾病的管理提供了新的见解。
