可溶性物质对血型抗体的抑制作用。
Inhibition of blood group antibodies by soluble substances.
作者信息
Byrne Karen M, Mercado Chloe Marie C, Nnabue Thaddeus N, Paige Traci D, Flegel Willy A
机构信息
SBB Program Education Coordinator, National Institutes of Health (NIH) Clinical Center, Department of Transfusion Medicine, 10 Center Drive, Bethesda, MD.
Reference Technologist, American Red Cross, Pomona, CA.
出版信息
Immunohematology. 2019 Jan;35(1):19-22.
The presence of multiple alloantibodies or an antibody to a highprevalance antigen in a patient sample can pose challenges in antibody identification. The pattern of reactivity seen on an antibody panel may show various strengths of reactivity by different methods of testing or same strength of reactivity at one or more phases of testing. To ensure proper identification, multiple investigative tools may be used. We review one of these methods-inhibition by soluble substances-which has become an expansion of our toolbox within the past 10 years. Alloantibodies can be inhibited using specific soluble substances. These soluble substances occur naturally in various fluids or can be manufactured. When a patient sample contains multiple antibodies, clinically significant or not, inhibition of one may help determine specificities of others. Specific inhibition of a particular antibody will also help to confirm its presence.
患者样本中存在多种同种抗体或针对高流行抗原的抗体，可能会给抗体鉴定带来挑战。在抗体筛查细胞上观察到的反应模式可能因不同的检测方法而显示出不同强度的反应，或者在一个或多个检测阶段显示相同强度的反应。为确保正确鉴定，可能会使用多种调查工具。我们回顾其中一种方法——可溶性物质抑制法，在过去10年里，它已成为我们工具库的扩展内容。同种抗体可以使用特定的可溶性物质进行抑制。这些可溶性物质天然存在于各种体液中，也可以人工制造。当患者样本含有多种抗体时，无论是否具有临床意义，抑制其中一种抗体可能有助于确定其他抗体的特异性。对特定抗体的特异性抑制也将有助于确认其存在。
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