生物信息学在细胞信号转导中的应用：KAMI 项目。
Bio-Curation for Cellular Signalling: The KAMI Project.
出版信息
IEEE/ACM Trans Comput Biol Bioinform. 2019 Sep-Oct;16(5):1562-1573. doi: 10.1109/TCBB.2019.2906164. Epub 2019 Mar 19.
PMID:30908261
Abstract
The general question of what constitutes bio-curation for rule-based modelling of cellular signalling is posed. A general approach to the problem is presented, based on rewriting in hierarchies of graphs, together with a specific instantiation of the methodology that addresses our particular bio-curation problem. The current state of the ongoing development of the KAMI bio-curation tool, based on this approach, is outlined along with our plans for future development.
摘要
提出了基于规则的细胞信号建模的生物策管的一般问题，即什么构成生物策管。提出了一种基于图形层次重写的一般方法，并针对我们特定的生物策管问题进行了具体实例化。概述了基于此方法的 KAMI 生物策管工具正在进行的开发的当前状态，以及我们未来的开发计划。
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