细胞信号网络的重建及其特性分析。
Reconstruction of cellular signalling networks and analysis of their properties.
作者信息
Papin Jason A, Hunter Tony, Palsson Bernhard O, Subramaniam Shankar
机构信息
Department of Bioengineering, 9500 Gilman Drive, Mail Code 0412, University of California, San Diego, La Jolla, California 92093-0412, USA.
出版信息
Nat Rev Mol Cell Biol. 2005 Feb;6(2):99-111. doi: 10.1038/nrm1570.
The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.
在过去20年里对细胞信号传导的研究以及高通量技术的出现，使得大规模信号网络的重建成为可能。在对信号网络进行仔细重建之后，必须在一个综合框架内描述其特性，该框架既要考虑细胞信号网络的复杂性，又要便于进行定量建模。
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