Centro de Investigación en Reproducción Animal, CINVESTAV- Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico.
Laboratorio Neuropsiquiatría. Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Drug Dev Res. 2019 Jun;80(4):513-518. doi: 10.1002/ddr.21528. Epub 2019 Mar 25.
Chronic inflammatory pain is a major health problem worldwide with high prevalence in women. Cerebrolysin is a multimodal neuropeptide preparation that crosses the blood brain barrier and displays neuroprotective properties in aging and disease. Previously, we showed that cerebrolysin reduced mechanical allodynia in a model of persistent inflammation and pain. We aim to build upon the findings of our previous study by investigating the response to acute administration of cerebrolysin in two models of peripheral inflammation and assessing sex differences. We utilized the complete Freund's adjuvant (CFA) that produces maximal oedema and mechanical allodynia within days and carrageenan that produces similar effects within hours. Cerebrolysin reversed the mechanical allodynia in both sexes in CFA-treated rats. On the other hand, in rats treated with carrageenan, cerebrolysin was only effective in reducing mechanical allodynia in female rats. In conclusion, the present study shows that cerebrolysin effects may be sex-specific depending on different mechanisms that are at play in these two models of peripheral inflammatory pain. Further investigations are required to determine the factors contributing to sex differences.
慢性炎症性疼痛是一个全球性的主要健康问题，在女性中发病率较高。脑活素是一种多模式神经肽制剂，可穿过血脑屏障，并在衰老和疾病中表现出神经保护特性。先前，我们表明脑活素可减轻持续性炎症和疼痛模型中的机械性痛觉过敏。我们旨在在前一项研究的基础上，通过研究两种外周炎症模型中脑活素急性给药的反应，并评估性别差异来进一步研究。我们使用完全弗氏佐剂（CFA），它在数天内产生最大水肿和机械性痛觉过敏，以及角叉菜胶，它在数小时内产生类似的效果。脑活素可逆转 CFA 处理大鼠的机械性痛觉过敏。另一方面，在角叉菜胶处理的大鼠中，脑活素仅能有效减轻雌性大鼠的机械性痛觉过敏。总之，本研究表明，脑活素的作用可能具有性别特异性，这取决于这两种外周炎症性疼痛模型中发挥作用的不同机制。需要进一步研究确定导致性别差异的因素。
