School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China.
Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L. CP 64849, Mexico.
Sci Total Environ. 2019 Jun 20;670:555-568. doi: 10.1016/j.scitotenv.2019.03.261. Epub 2019 Mar 20.
In recent years, the use of cosmeceutical-based personal care and beauty products has ever increased, around the world. Currently, an increasing number of compounds are being assimilated in the formulation of cosmetic products as preservatives, fragrances, surfactants, etc. to intensify the performance, quality, value, and lifespan of cosmetics. Nevertheless, many of these chemical additives pose toxic effects to the human body, exhibiting health risks from a mild hypersensitivity to life-threatening anaphylaxis or lethal intoxication. Therefore, the indiscriminate application of cosmeceuticals has recently become a mounting issue confronting public health. The present review focuses on exposure to a large variety of toxic substances used in cosmetic formulations such as 1,4-dioxane formaldehyde, paraformaldehyde, benzalkonium chloride, imidazolidinyl urea, diazolidinyl urea, trace heavy metals, parabens derivatives, phthalates, isothiazolinone derivatives (methylchloroiso-thiazolinone, and methylisothiazolinone), methyldibromo glutaronitrile, and phenoxy-ethanol. The biological risks related to these substances that they can pose to human health in terms of cytotoxicity, genotoxicity, mutagenicity, neurotoxicity oestrogenicity or others are also discussed. Researchers from academia, consultancy firms, governmental organizations, and cosmetic companies should carry out further progress to keep updating the consumers regarding the dark-sides, and health-related harmful apprehensions of cosmetics. In addition, the industry-motivated initiatives to abate environmental impact through green, sustainable and eco-friendly product development grasp significant perspective.
近年来，全球范围内，基于化妆品的个人护理和美容产品的使用量不断增加。目前，越来越多的化合物被作为防腐剂、香料、表面活性剂等被同化到化妆品的配方中，以提高化妆品的性能、质量、价值和寿命。然而，这些化学添加剂中的许多对人体都有有毒作用，表现出从轻度过敏到威胁生命的过敏反应或致命中毒的健康风险。因此，化妆品的滥用问题最近成为了一个公共卫生面临的重要问题。本综述重点关注暴露于大量化妆品配方中使用的有毒物质，如 1,4-二恶烷甲醛、多聚甲醛、苯扎氯铵、咪唑烷基脲、双脒基脲、痕量重金属、对羟基苯甲酸酯衍生物、邻苯二甲酸酯、异噻唑啉酮衍生物（甲基氯异噻唑啉酮和甲基异噻唑啉酮）、甲二溴戊二腈和苯氧乙醇。还讨论了这些物质对人类健康可能造成的细胞毒性、遗传毒性、致突变性、神经毒性、雌激素性或其他毒性相关的生物风险。学术界、咨询公司、政府组织和化妆品公司的研究人员应该进一步开展工作，让消费者了解化妆品的阴暗面以及与健康相关的有害问题。此外，通过绿色、可持续和生态友好型产品开发来减轻环境影响的行业驱动举措具有重要意义。
